Wang Yong-Fei, Dong Zi-Kai, Jin Wei-Lin
Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Clinical Medical College, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, 730000, People's Republic of China.
Mol Cancer. 2025 Jul 25;24(1):206. doi: 10.1186/s12943-025-02396-6.
Cancer research is undergoing a paradigm shift from solely studying tumor cells to investigating systemic effects of cancer in the tumor macroevironment, with an emphasis on the interactions between host organs and tumors. The theory of homeostasis is an important basis for explaining biological functions from the perspective of the organism. Organic homeostasis relies on brain-body crosstalk through interception, immunoception, nociception and other supervisory processes, guaranteeing normal physiological function. Recent studies reveal that malignant tumors can hijack and exploit the brain and its central-peripheral neuronal networks to disrupt the body's homeostasis. Tumors likely disrupt normal brain-body crosstalk by establishing bidirectional brain-tumor connections. On the contrary, organism utilize these mechanisms to hinder tumorigenesis and progression. Standing at the perspective of brain-body crosstalk also promotes the conceptional evolution of cancer initiation and development, and more importantly, provides additional insight for cancer treatment. In this review, we summarize current knowledge about brain-body crosstalk under tumor-bearing contexts and propose some novel anti-cancer strategies.
癌症研究正在经历一场范式转变，从单纯研究肿瘤细胞转向研究肿瘤宏观环境中癌症的全身效应，重点是宿主器官与肿瘤之间的相互作用。稳态理论是从生物体角度解释生物学功能的重要基础。机体稳态依赖于通过截获、免疫感知、伤害感受和其他监管过程实现的脑-体串扰，以保证正常生理功能。最近的研究表明，恶性肿瘤可以劫持并利用大脑及其中枢-外周神经网络来破坏身体的稳态。肿瘤可能通过建立双向脑-肿瘤连接来扰乱正常的脑-体串扰。相反，机体利用这些机制来阻碍肿瘤发生和进展。从脑-体串扰的角度出发，也促进了癌症发生和发展概念的演变，更重要的是，为癌症治疗提供了新的见解。在这篇综述中，我们总结了目前关于荷瘤情况下脑-体串扰的知识，并提出了一些新的抗癌策略。
