Shamohammadi Mohammadsadra, Eskandari Delaram, Ziaee Amir, Samadanifard Seyed Hossein, Chehrehgosha Haleh, Ghanooni Amir Hossein
Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
M.D., Endocrinologist Assistant Professor of Internal Medicine Assistant Professor of Internal Medicine, Iran University of Medical Sciences at Rasool Akram General Hospital, Tehran, Iran.
J Med Case Rep. 2025 Jul 25;19(1):366. doi: 10.1186/s13256-025-05428-3.
Cushing's syndrome is an uncommon but serious condition caused by long-term exposure to elevated cortisol levels, which is usually iatrogenic in origin. Although systemic corticosteroids are the most frequent agents, the association of intranasal corticosteroids with this condition is remarkably rare.
This report is about a 21-year-old Iranian woman using betamethasone nasal drops for nasal obstruction. The patient presented with weight gain, Amenorrhea, mood disturbances, red purplish striae, and mild hirsutism. Hormonal assessments revealed suppression of the hypothalamic-pituitary-adrenal axis.
This case demonstrates the underappreciated systemic effects of intranasal betamethasone to induce Cushing's syndrome. It serves as a pivotal reminder of the need for vigilance in prescribing practices and reinforces the importance of early diagnosis to ensure favorable patient outcomes.
库欣综合征是一种由长期暴露于升高的皮质醇水平引起的罕见但严重的病症，其起源通常为医源性。虽然全身用皮质类固醇是最常见的药物，但鼻用皮质类固醇与这种病症的关联极为罕见。
本报告讲述的是一名21岁的伊朗女性，因鼻塞使用倍他米松滴鼻剂。该患者出现体重增加、闭经、情绪障碍、紫红色条纹和轻度多毛症。激素评估显示下丘脑 - 垂体 - 肾上腺轴受到抑制。
该病例表明鼻用倍他米松诱导库欣综合征的全身作用未得到充分认识。它提醒人们在处方实践中需要保持警惕，并强化了早期诊断以确保患者获得良好预后的重要性。
