Elghannam Maged Tharwat, Hassanien Moataz Hassan, Ameen Yosry Abdelrahman, Turky Emad Abdelwahab, ELattar Gamal Mohammed, ELRay Ahmed Aly, ELTalkawy Mohammed Darwish
Hepatogastroenterology Department, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Gut Pathog. 2025 Jul 26;17(1):56. doi: 10.1186/s13099-025-00729-w.
The development of gastric cancer is significantly influenced by the intestinal microbiota, with H. pylori serving as a major risk factor. Through genotoxic effects, persistent inflammation, and metabolic changes, other microbes also play a role. It has been demonstrated that cancer patients and healthy people have different microbiome compositions. Cancer can be inhibited or promoted by the gut microbiota and its metabolites. The relationship between intestinal flora, bacterial extracellular vesicles, and the tumor microenvironment directly affects tumor progression and efficacy of anti-tumor medications, indicating the importance of the tumor microenvironment in tumor survival. Gastrointestinal malignancies may be brought on by the gut microbiome's dysregulation of non-coding RNA expression. Non-coding RNAs are intriguing avenues for future therapeutic and diagnostic research. The tumor microenvironment is altered by bacterial extracellular vesicles, which may have an effect on immunosuppression, treatment resistance, metastasis, and cancer progression. Further research is required to completely understand the involvement of non-coding RNAs in GI cancers. By modifying drug metabolism and absorption, which have a substantial impact on healing efficacy and serious impact profiles, the dynamic changes in gut microbiota also have a considerable impact on the results of anti-cancer treatment. Improved treatment approaches may arise from a better understanding of the role of the microbiome in gastric malignancies.
胃癌的发展受到肠道微生物群的显著影响，幽门螺杆菌是主要危险因素。通过基因毒性作用、持续性炎症和代谢变化，其他微生物也发挥作用。已有研究表明，癌症患者和健康人的微生物组组成不同。肠道微生物群及其代谢产物可抑制或促进癌症。肠道菌群、细菌细胞外囊泡与肿瘤微环境之间的关系直接影响肿瘤进展和抗肿瘤药物疗效，表明肿瘤微环境在肿瘤生存中的重要性。胃肠道恶性肿瘤可能由肠道微生物群对非编码RNA表达的失调引起。非编码RNA是未来治疗和诊断研究的有趣途径。细菌细胞外囊泡改变肿瘤微环境，这可能影响免疫抑制、治疗耐药性、转移和癌症进展。需要进一步研究以全面了解非编码RNA在胃肠道癌症中的作用。肠道微生物群的动态变化通过改变药物代谢和吸收，对愈合疗效和严重影响特征有重大影响，也对抗癌治疗结果有相当大的影响。更好地理解微生物组在胃癌中的作用可能会产生改进的治疗方法。
