Cui Longzhu, Watanabe Shinya, Miyanaga Kazuhiko, Kiga Kotaro, Sasahara Teppei, Aiba Yoshifumi, Tan Xin-Ee, Veeranarayanan Srivani, Thitiananpakorn Kanate, Nguyen Huong Minh, Wannigama Dhammika Leshan
Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical University, Shimotsuke City 329-0498, Japan.
Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Antibiotics (Basel). 2024 Sep 11;13(9):870. doi: 10.3390/antibiotics13090870.
Phage therapy, the use of bacteriophages (phages) to treat bacterial infections, is regaining momentum as a promising weapon against the rising threat of multidrug-resistant (MDR) bacteria. This comprehensive review explores the historical context, the modern resurgence of phage therapy, and phage-facilitated advancements in medical and technological fields. It details the mechanisms of action and applications of phages in treating MDR bacterial infections, particularly those associated with biofilms and intracellular pathogens. The review further highlights innovative uses of phages in vaccine development, cancer therapy, and as gene delivery vectors. Despite its targeted and efficient approach, phage therapy faces challenges related to phage stability, immune response, and regulatory approval. By examining these areas in detail, this review underscores the immense potential and remaining hurdles in integrating phage-based therapies into modern medical practices.
噬菌体疗法，即利用噬菌体来治疗细菌感染，正作为对抗多重耐药（MDR）细菌日益增长威胁的一种有前景的武器而重新获得发展势头。这篇全面的综述探讨了噬菌体疗法的历史背景、现代复兴以及噬菌体在医学和技术领域推动的进展。它详细阐述了噬菌体在治疗MDR细菌感染，特别是与生物膜和细胞内病原体相关的感染中的作用机制和应用。该综述还进一步强调了噬菌体在疫苗开发、癌症治疗以及作为基因递送载体方面的创新用途。尽管噬菌体疗法具有针对性和高效性，但它面临着与噬菌体稳定性、免疫反应和监管批准相关的挑战。通过详细研究这些领域，本综述强调了将基于噬菌体的疗法整合到现代医学实践中的巨大潜力和尚存的障碍。
