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Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for 2 Weeks.极早产儿出生后随机接受以捐赠母乳强化剂进行为期2周的早期母乳强化，其支气管肺发育不良的严重程度
J Pediatr. 2025 Jul 24;287:114750. doi: 10.1016/j.jpeds.2025.114750.
2
Early full enteral nutrition with fortified milk in very preterm infants: a randomized clinical trial.极早产儿早期使用强化牛奶进行全肠内营养：一项随机临床试验。
Am J Clin Nutr. 2025 May;121(5):1117-1123. doi: 10.1016/j.ajcnut.2025.02.019. Epub 2025 Feb 21.
3
Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.预防性或极早期开始持续气道正压通气（CPAP）治疗早产儿。
Cochrane Database Syst Rev. 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4.
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Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial.以人乳为基础的强化剂对纯母乳喂养的极早产儿的影响：一项随机对照试验。
EClinicalMedicine. 2024 Jan 2;68:102375. doi: 10.1016/j.eclinm.2023.102375. eCollection 2024 Feb.
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Late (> 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.晚期（>7天）全身性产后皮质类固醇用于预防早产儿支气管肺发育不良
Cochrane Database Syst Rev. 2017 Oct 24;10(10):CD001145. doi: 10.1002/14651858.CD001145.pub4.
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Effect of Multi-Nutrient Milk Fortification on Preterm Neonate Outcomes: A Network Meta-Analysis.多种营养素强化牛奶对早产儿结局的影响：一项网状Meta分析
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Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates.吸入性糖皮质激素与全身性糖皮质激素预防机械通气的极低出生体重早产儿支气管肺发育不良的比较
Cochrane Database Syst Rev. 2017 Oct 17;10(10):CD002058. doi: 10.1002/14651858.CD002058.pub3.
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Early (< 8 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.早期（<8天）全身性产后使用皮质类固醇预防早产儿支气管肺发育不良
Cochrane Database Syst Rev. 2017 Oct 24;10(10):CD001146. doi: 10.1002/14651858.CD001146.pub5.
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Cup feeding versus other forms of supplemental enteral feeding for newborn infants unable to fully breastfeed.对于无法完全进行母乳喂养的新生儿，奶瓶喂养与其他形式的补充肠内喂养的比较。
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Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth weight preterm infants.吸入性糖皮质激素与全身性糖皮质激素治疗机械通气的极低出生体重早产儿支气管肺发育不良的比较
Cochrane Database Syst Rev. 2017 Oct 16;10(10):CD002057. doi: 10.1002/14651858.CD002057.pub4.

本文引用的文献

1
Hour of Life at Enteral Feeding Initiation and Associated Clinical Morbidity in Extremely Low-Birth-Weight Infants.极低出生体重儿开始肠内喂养时的生命时长及相关临床发病率
Nutrients. 2024 Nov 26;16(23):4041. doi: 10.3390/nu16234041.
2
Post-Discharge Growth Among Extremely Preterm Infants With or Without Bronchopulmonary Dysplasia.有或无支气管肺发育不良的极早产儿出院后的生长情况
Pediatr Pulmonol. 2025 Jan;60(1):e27388. doi: 10.1002/ppul.27388. Epub 2024 Nov 8.
3
Risk Assessment of Cognitive Impairment at 2 Years of Age in Infants Born Extremely Preterm Using the INTERGROWTH-21st Growth Standards.采用 INTERGROWTH-21st 生长标准评估极早产儿 2 岁时认知障碍的风险。
J Pediatr. 2024 Dec;275:114239. doi: 10.1016/j.jpeds.2024.114239. Epub 2024 Aug 19.
4
Nutritional support during the first week for infants with bronchopulmonary dysplasia and respiratory distress: a multicenter cohort study in China.支气管肺发育不良和呼吸窘迫婴儿第一周的营养支持：中国多中心队列研究。
BMC Pediatr. 2024 Apr 3;24(1):238. doi: 10.1186/s12887-024-04675-5.
5
Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial.以人乳为基础的强化剂对纯母乳喂养的极早产儿的影响：一项随机对照试验。
EClinicalMedicine. 2024 Jan 2;68:102375. doi: 10.1016/j.eclinm.2023.102375. eCollection 2024 Feb.
6
Association of Fortification with Human Milk versus Bovine Milk-Based Fortifiers on Short-Term Outcomes in Preterm Infants-A Meta-Analysis.强化人乳与牛基强化剂对早产儿短期结局的影响：一项荟萃分析。
Nutrients. 2024 Mar 21;16(6):910. doi: 10.3390/nu16060910.
7
Early Human Milk Fortification in Infants Born Extremely Preterm: A Randomized Trial.早产儿母乳喂养强化：一项随机试验。
Pediatrics. 2023 Sep 1;152(3). doi: 10.1542/peds.2023-061603.
8
Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts.早产儿肠内营养（2022）：ESP-GHAN 营养委员会及特邀专家的立场文件。
J Pediatr Gastroenterol Nutr. 2023 Feb 1;76(2):248-268. doi: 10.1097/MPG.0000000000003642. Epub 2022 Oct 28.
9
Association of Postnatal Growth Changes and Neurodevelopmental Outcomes in Preterm Neonates of <29 Weeks' Gestation.29 周以下早产儿的产后生长变化与神经发育结局的相关性研究。
J Pediatr. 2023 May;256:63-69.e2. doi: 10.1016/j.jpeds.2022.11.039. Epub 2022 Dec 9.
10
Adjustment for Baseline Characteristics in Randomized Clinical Trials.随机临床试验中基线特征的调整
JAMA. 2022 Dec 6;328(21):2155-2156. doi: 10.1001/jama.2022.21506.

极早产儿出生后随机接受以捐赠母乳强化剂进行为期2周的早期母乳强化，其支气管肺发育不良的严重程度

Severity of Bronchopulmonary Dysplasia in Infants Born Extremely Preterm and Randomized to Early Human Milk Fortification with a Donor Milk-Derived Fortifier for 2 Weeks.

作者信息

Tucker Marley J, Jeffcoat Seabrook H, Argent Tori, Travers Colm P, Salas Ariel A

机构信息

Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.

Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.

出版信息

J Pediatr. 2025 Jul 24;287:114750. doi: 10.1016/j.jpeds.2025.114750.

DOI:10.1016/j.jpeds.2025.114750
PMID:40714049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12382184/
Abstract

In this secondary analysis of a masked clinical trial involving 150 infants born extremely preterm randomized to receive fortified milk starting on either postnatal day 3 (early group) or day 14 (delayed group), we found a significant difference in the distribution of bronchopulmonary dysplasia severity between the 2 groups (P = .039) with milder forms of bronchopulmonary dysplasia in the early group.

摘要

在这项对一项涉及150名极早产婴儿的双盲临床试验的二次分析中，这些婴儿被随机分为两组，一组从出生后第3天开始接受强化牛奶（早期组），另一组从出生后第14天开始接受强化牛奶（延迟组），我们发现两组之间支气管肺发育不良严重程度的分布存在显著差异（P = 0.039），早期组的支气管肺发育不良形式较轻。