一种与胃肠道和卵巢肿瘤相关的疑似新抗原（CSAp）。

A putatively new antigen (CSAp) associated with gastrointestinal and ovarian neoplasia.

作者信息

Pant K D, Dahlman H L, Goldenberg D M

出版信息

Immunol Commun. 1977;6(4):411-21. doi: 10.3109/08820137709051977.

DOI:10.3109/08820137709051977

Abstract

CSAp is an antigen originally identified in the GW-39 human colonic carcinoma xenograft, and also found in gastric and colonic cancers, fetal colon, normal and inflammatory adult colon, and in some ovarian tumors. However, it appears to be increased primarily in inflammatory, benign , malignant, and fetal human intestine, gastric cancer, and ovarian tumors, as determined by an hemagglutination-inhibition assay. Gel immunodiffusion patterns show that CSAp is immunologically distinct from CEA, NCA, AFP, BOFA, and human liver ferritin. CSAp thus appears to be a putatively new fetal substance with a high degree of specificity for gastric, colonic, and ovarian tissues.

摘要

癌特异性抗原p（CSAp）是最初在GW - 39人结肠癌异种移植物中鉴定出的一种抗原，也存在于胃癌、结肠癌、胎儿结肠、正常及炎性成人结肠以及某些卵巢肿瘤中。然而，通过血凝抑制试验测定发现，它似乎主要在炎性、良性、恶性及胎儿的人类肠道、胃癌和卵巢肿瘤中含量增加。凝胶免疫扩散图谱显示，CSAp在免疫学上与癌胚抗原（CEA）、非癌胚抗原（NCA）、甲胎蛋白（AFP）、血型癌胚抗原（BOFA）及人肝铁蛋白不同。因此，CSAp似乎是一种对胃、结肠和卵巢组织具有高度特异性的假定新型胎儿物质。