Law F C, Chakrabarti S
Toxicology. 1985 Dec;37(3-4):275-84. doi: 10.1016/0300-483x(85)90091-5.
The isolated perfused lung (IPL) of rats were used to examine the pulmonary disposition and metabolism of radiolabeled phencyclidine (PCP) and N-ethyl-1-phenylcyclohexylamine (PCE). The IPL removed PCP and PCE from the perfusate and converted them to free and conjugated metabolites. At the conclusion of a 1-h perfusion, the lung accumulated at least 20% of the administered radioactivity and metabolized more than 30% of the added drug. Pretreatment of rats with 3-MC or cigarette smoke enhanced significantly PCP and PCE metabolism by the IPL. The concentration of conjugated PCE metabolite in the perfusate of the IPL was increased significantly by both 3-MC and cigarette smoke pretreatments whereas the concentration of conjugated PCP metabolite was not affected by cigarette smoke exposure and increased only slightly after 3-MC pretreatment. Pretreatment of rats with 3-MC or cigarette smoke also altered the amount of radioactivity accumulated by the lung tissue at the conclusion of a 1-h perfusion. Inasmuch as PCP and PCE are often abused by humans via smoke inhalation, a significant amount of these drugs may be stored or metabolized by the lung.
使用大鼠离体灌注肺（IPL）来研究放射性标记的苯环己哌啶（PCP）和N-乙基-1-苯基环己胺（PCE）的肺部处置和代谢情况。IPL从灌注液中清除PCP和PCE，并将它们转化为游离和结合代谢物。在1小时灌注结束时，肺积累了至少20%的给药放射性，并代谢了超过30%的添加药物。用3-甲基胆蒽（3-MC）或香烟烟雾预处理大鼠可显著增强IPL对PCP和PCE的代谢。3-MC和香烟烟雾预处理均显著增加了IPL灌注液中结合型PCE代谢物的浓度，而结合型PCP代谢物的浓度不受香烟烟雾暴露的影响，仅在3-MC预处理后略有增加。用3-MC或香烟烟雾预处理大鼠还改变了1小时灌注结束时肺组织积累的放射性量。鉴于PCP和PCE常被人类通过吸入烟雾滥用，这些药物的大量可能会被肺储存或代谢。
