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定制3D打印多孔钛增强体用于Paprosky III型髋臼缺损:结合生物力学原理与早期临床结果的病例系列

Custom 3D-printed porous titanium augments for Paprosky type III acetabular defects: a case series combining biomechanical rationale with early clinical outcomes.

作者信息

Shi Tengbin, Zhang Wenming, Fang Xinyu

机构信息

Department of Orthopedic Surgery, Fujian Medical University Union Hospital, Fuzhou, 350000, China.

Fujian Medical Unversity, Fuzhou, China.

出版信息

3D Print Med. 2025 Jul 26;11(1):41. doi: 10.1186/s41205-025-00293-8.

DOI:10.1186/s41205-025-00293-8
PMID:40715922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12297843/
Abstract

BACKGROUND

Severe acetabular bone defects (Paprosky type III) pose significant challenges for reconstruction and stable implant fixation. This study aimed to analyze the biomechanical properties and clinical safety of personalized 3D-printed porous titanium alloy reinforcement augments and evaluate their therapeutic efficacy in reconstructing these complex defects.

METHODS

We reviewed three cases of Paprosky type III acetabular defects reconstructed using personalized 3D-printed porous titanium alloy augments. Finite element analysis (FEA) simulated the defects, utilizing a commercial augment as a control. Stress distribution within the augments, fixation screws, acetabular cups, and surrounding bone was analyzed under simulated single-leg standing (1 × body weight), walking (4 × BW), and jogging (6 × BW) loading conditions, with comparisons made to the control.

RESULTS

Under all loading conditions, the peak stresses observed on the augment screws and acetabular cups in all three cases were lower than the buckling strength of titanium alloy and were consistently lower than those recorded in the control group. This indicates that the personalized augments provided stable support for acetabular cup fixation, aiding in the restoration of the hip rotation center and lower limb length.

CONCLUSIONS

Personalized 3D-printed porous titanium alloy augments demonstrate favorable biomechanical safety and clinical efficacy based on FEA and initial case review. For severe acetabular bone defects, these custom augments offer good initial stability, promoting bone integration for long-term fixation, and potentially reducing risks associated with cup loosening, dislocation, and periprosthetic fracture.

摘要

背景

严重髋臼骨缺损(Paprosky III型)给重建和稳定植入物固定带来了重大挑战。本研究旨在分析个性化3D打印多孔钛合金增强物的生物力学性能和临床安全性,并评估其在重建这些复杂缺损中的治疗效果。

方法

我们回顾了3例使用个性化3D打印多孔钛合金增强物重建的Paprosky III型髋臼缺损病例。有限元分析(FEA)模拟缺损情况,以商用增强物作为对照。在模拟单腿站立(1×体重)、行走(4×体重)和慢跑(6×体重)负荷条件下,分析增强物、固定螺钉、髋臼杯及周围骨骼内的应力分布,并与对照组进行比较。

结果

在所有负荷条件下,3例病例中增强物螺钉和髋臼杯上观察到的峰值应力均低于钛合金的屈曲强度,且始终低于对照组记录的值。这表明个性化增强物为髋臼杯固定提供了稳定支撑,有助于恢复髋关节旋转中心和下肢长度。

结论

基于有限元分析和初步病例回顾,个性化3D打印多孔钛合金增强物显示出良好的生物力学安全性和临床疗效。对于严重髋臼骨缺损,这些定制增强物提供了良好的初始稳定性,促进骨整合以实现长期固定,并可能降低与髋臼杯松动、脱位和假体周围骨折相关的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/fb30f3d3416d/41205_2025_293_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/3537ec7be87f/41205_2025_293_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/ebd55ccf9944/41205_2025_293_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/3b57bceb99e2/41205_2025_293_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/454436d1e3aa/41205_2025_293_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/ac26400175a7/41205_2025_293_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/9dc915f9eafc/41205_2025_293_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/9185ee1dc7d1/41205_2025_293_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/fb30f3d3416d/41205_2025_293_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/3537ec7be87f/41205_2025_293_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/ebd55ccf9944/41205_2025_293_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/3b57bceb99e2/41205_2025_293_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/454436d1e3aa/41205_2025_293_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/ac26400175a7/41205_2025_293_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/9dc915f9eafc/41205_2025_293_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/9185ee1dc7d1/41205_2025_293_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e45/12297843/fb30f3d3416d/41205_2025_293_Fig8_HTML.jpg

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