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伤寒:临床表现及对氯霉素的反应。1972年在孟买进行的前瞻性研究。

Typhoid: clinical picture and response to chloramphenicol. Prospective study in Bombay (1972).

作者信息

Kamat S A, Herzog C

出版信息

Infection. 1977;5(2):85-91. doi: 10.1007/BF01642086.

DOI:10.1007/BF01642086
PMID:407164
Abstract

The clinical picture of 78 cases with proven typhoid and 18 cases with proven paratyphoid A fever is presented. The diagnosis was made by isolating the organisms from the blood. The Widal test could not be used as a diagnostic criterion. By means of chemotherapy with chloramphenicol (initial dose 30-40 mg/kg body weight) defervescence was achieved within an average of 4.5 days. The course of the disease was generally mild; one patient with typhoid fever died. The average hospital stay was 19 days. Four patients of the typhoid fever group were readmitted with a relapse. The laboratory examinations included blood clot culture, phage typing, Widal test, haemoglobin, leucocyte count, transaminases, serum bilirubin, and routine examination and culture of stool and urine. Forty-two patients were infected with intestinal parasites and 25 with Shigella organism. The findings are discussed and compared with findings of similar studies of enteric fever.

摘要

本文呈现了78例确诊伤寒患者和18例确诊甲型副伤寒患者的临床表现。诊断通过从血液中分离出病原体得出。维达试验不能用作诊断标准。通过使用氯霉素化疗(初始剂量为30 - 40毫克/千克体重),平均在4.5天内实现退热。疾病进程总体较轻;1例伤寒患者死亡。平均住院时间为19天。伤寒热组有4例患者复发再次入院。实验室检查包括血凝块培养、噬菌体分型、维达试验、血红蛋白、白细胞计数、转氨酶、血清胆红素以及粪便和尿液的常规检查与培养。42例患者感染肠道寄生虫,25例感染志贺氏菌属微生物。对这些发现进行了讨论,并与类似的伤寒热研究结果进行了比较。

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Infection. 1977;5(2):85-91. doi: 10.1007/BF01642086.
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本文引用的文献

1
Typhoid; clinical analysis of 360 cases.伤寒;360例临床分析
Arch Intern Med (Chic). 1946 Dec;78(6):629-61. doi: 10.1001/archinte.1946.00220060002001.
2
Preliminary report on the beneficial effect of chloromycetin in the treatment of typhoid fever.氯霉素治疗伤寒热疗效的初步报告。
Ann Intern Med. 1948 Jul;29(1):131-4. doi: 10.7326/0003-4819-29-1-131.
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TYPHOID AND PARATYPHOID FEVERS IN PANJAB (INDIA): A STUDY OF 340 CASES.印度旁遮普邦的伤寒和副伤寒热:340例病例研究
Am J Trop Med Hyg. 1965 May;14:419-23. doi: 10.4269/ajtmh.1965.14.419.
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COMPLICATIONS, PROGNOSIS AND RELAPSE IN TYPHOID FEVER.伤寒热的并发症、预后及复发
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The complications of typhoid fever.伤寒热的并发症。
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