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孕期及出生时的全氟和多氟烷基物质浓度与儿童急性淋巴细胞白血病风险

Per- and polyfluoroalkyl substance concentrations during pregnancy and at birth and risk of childhood acute lymphoblastic leukemia.

作者信息

Morimoto Libby M, Metayer Catherine, Dolios Georgia, Wiemels Joseph L, Ma Xiaomei, Guan Haibin, Maroli Amith, Petrick Lauren M

机构信息

School of Public Health, University of California, Berkeley, CA, USA.

School of Public Health, University of California, Berkeley, CA, USA.

出版信息

Environ Res. 2025 Jul 25;285(Pt 3):122436. doi: 10.1016/j.envres.2025.122436.

Abstract

BACKGROUND

Per- and polyfluoroalkyl substances (PFAS) comprise a class of persistent environmental pollutants with potential carcinogenic effects, but their impact on childhood cancer remains underexplored. A child's exposure to PFAS can occur through various pathways postnatally, including contaminated food, water, and consumer products; and in utero, as PFAS can cross the placenta.

METHODS

To investigate the association between early-life PFAS exposure and the risk of childhood acute lymphoblastic leukemia (ALL), we analyzed archived blood samples from children diagnosed with ALL and matched cancer-free controls. Using novel untargeted liquid chromatography-high resolution mass spectrometry (LC-HRMS), we measured PFAS levels in paired maternal pregnancy and child newborn blood samples.

RESULTS

Our study identified an independent association between MeFOSAA levels at birth and increased ALL risk, particularly among children diagnosed at 2 years of age or younger. MeFOSAA measured in maternal second-trimester blood showed a weak association with ALL, although it was not statistically significant.

CONCLUSIONS

These results suggest that early-life exposure to MeFOSAA may play a critical role in the development of childhood ALL. Our findings corroborate previous reports linking MeFOSAA exposure during pregnancy to childhood ALL, highlighting its potential carcinogenicity during key developmental windows.

摘要

背景

全氟和多氟烷基物质(PFAS)是一类具有潜在致癌作用的持久性环境污染物,但其对儿童癌症的影响仍未得到充分研究。儿童接触PFAS可在出生后通过多种途径发生,包括受污染的食物、水和消费品;在子宫内也可接触到,因为PFAS能够穿过胎盘。

方法

为了研究生命早期PFAS暴露与儿童急性淋巴细胞白血病(ALL)风险之间的关联,我们分析了被诊断为ALL的儿童以及配对的无癌对照儿童的存档血样。使用新型非靶向液相色谱-高分辨率质谱(LC-HRMS),我们测量了配对的母亲孕期血样和儿童新生儿血样中的PFAS水平。

结果

我们的研究发现出生时的MeFOSAA水平与ALL风险增加之间存在独立关联,尤其是在2岁及以下被诊断的儿童中。在母亲孕中期血样中测得的MeFOSAA与ALL存在微弱关联,尽管在统计学上不显著。

结论

这些结果表明,生命早期暴露于MeFOSAA可能在儿童ALL的发生发展中起关键作用。我们的研究结果证实了先前关于孕期接触MeFOSAA与儿童ALL相关的报道,突出了其在关键发育窗口期的潜在致癌性。

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