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ICU 肠内营养患者并发再喂养综合征的影响因素分析及护理策略

Analysis of influencing factors and nursing strategies for enteral nutrition patients complicated with refeeding syndrome in ICU.

作者信息

Yan Dongmei, Wang Jian

机构信息

Department of Critical Care Medicine, Guang'an People's Hospital, No.1, Section 4, Binhe Road, Guang'an District, Guang'an city, Sichuan Province, 638000, China.

出版信息

BMC Gastroenterol. 2025 Jul 28;25(1):534. doi: 10.1186/s12876-025-04122-4.

Abstract

OBJECTIVE

To analyze the influencing factors and nursing strategies for enteral nutrition patients complicated with refeeding syndrome (RS) in the ICU.

METHODS

A total of 173 enteral nutrition patients in the ICU admitted to our hospital from January 2020 to January 2021 were retrospectively analyzed. Patients were divided into a control group (without RS, n = 128) and an observation group (with RS, n = 45) based on whether they developed RS. The general data such as gender, age, and body mass index (BMI) of patients were compared. The enteral nutrition-related indexes of two groups such as gastrointestinal decompression before feeding, diuretic application before feeding, and parenteral nutrition were compared. The risk factors of RS in ICU enteral nutrition patients were analyzed by multivariate logistic regression. Patients in the observation group received targeted nursing strategies according to the risk factors. The levels of serum phosphorus, potassium, magnesium, albumin, and prealbumin were detected before and after nursing intervention.

RESULTS

The proportion of age ≥ 60 years, BMI ≥ 18.5 kg/m, diabetes history, cerebrovascular disease, severe pneumonia, acute physiology and chronic health evaluation (APACHE) II score > 20, duration of mechanical ventilation ≥ 3 days, NRS 2002 rating high risk in the observation group was much higher than that in the control group (P < 0.05). The observation group had a much higher proportion of whole protein nutrient solution, nasoenteric tube feeding, protein intake ≥ 1.2 g/kg, feeding speed > 50 ml/h, and enteral nutrition temperature 36-38℃ than the control group (P < 0.05). Multivariate logistic regression analysis pointed out that age ≥ 60 years, NRS 2002 score > 5, duration of mechanical ventilation ≥ 3 days, APACHE II score > 20, feeding speed > 50 ml/h, protein intake ≥ 1.2 g/kg, and enteral nutrition temperature 36-38℃ were independent risk factors of enteral nutrition patients complicated with RS in ICU (P < 0.05). After the intervention of targeted nursing strategies, the serum levels of phosphorus, potassium, magnesium, albumin, and prealbumin were obviously elevated than before (P < 0.05).

CONCLUSION

Age, NRS 2002 score, mechanical ventilation time, APACHE II score, feeding speed, protein intake, and enteral nutrition temperature are all risk factors of refeeding syndrome in ICU enteral nutrition patients. Targeted nursing intervention according to the influencing factors can effectively improve the efficacy of enteral nutrition and reduce or prevent other complications.

摘要

目的

分析重症监护病房(ICU)肠内营养患者并发再喂养综合征(RS)的影响因素及护理策略。

方法

回顾性分析2020年1月至2021年1月我院ICU收治的173例肠内营养患者。根据是否发生RS将患者分为对照组(未发生RS,n = 128)和观察组(发生RS,n = 45)。比较患者的性别、年龄、体重指数(BMI)等一般资料。比较两组的肠内营养相关指标,如喂养前胃肠减压、喂养前利尿剂应用及肠外营养情况。采用多因素logistic回归分析ICU肠内营养患者发生RS的危险因素。观察组根据危险因素采取针对性护理策略。护理干预前后检测血清磷、钾、镁、白蛋白及前白蛋白水平。

结果

观察组年龄≥60岁、BMI≥18.5 kg/m²、有糖尿病史、脑血管疾病史、重症肺炎、急性生理与慢性健康状况评分(APACHE)Ⅱ>20分、机械通气时间≥3天、营养风险筛查2002(NRS 2002)评分高风险的比例均明显高于对照组(P<0.05)。观察组全蛋白营养制剂、鼻肠管喂养、蛋白质摄入量≥1.2 g/kg、喂养速度>50 ml/h、肠内营养温度3638℃的比例均高于对照组(P<0.05)。多因素logistic回归分析指出,年龄≥60岁、NRS 2002评分>5分、机械通气时间≥3天、APACHEⅡ评分>20分、喂养速度>50 ml/h、蛋白质摄入量≥1.2 g/kg、肠内营养温度3638℃是ICU肠内营养患者并发RS的独立危险因素(P<0.05)。采取针对性护理策略干预后,血清磷、钾、镁、白蛋白及前白蛋白水平较干预前明显升高(P<0.05)。

结论

年龄、NRS 2002评分、机械通气时间、APACHEⅡ评分、喂养速度、蛋白质摄入量及肠内营养温度均是ICU肠内营养患者发生再喂养综合征的危险因素。根据影响因素采取针对性护理干预可有效提高肠内营养效果,减少或预防其他并发症。

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