Du Guimei, Li Xinghui
Department of Dermatology, The 906th Hospital of PLA, Ningbo, Zhejiang, China.
Department of Dermatology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, Jiangsu, China.
Front Pediatr. 2025 Jul 11;13:1557186. doi: 10.3389/fped.2025.1557186. eCollection 2025.
There are few studies investigating the relationship between vitamin B6 status and the odds of eczema in children and adolescents. Hereby, this study aims to explore the association between vitamin B6 status and eczema in children and adolescents.
A cross-sectional study was conducted based on National Health and Nutrition Examination Surveys (NHANES) 2005-2006. The vitamin B6 status was assessed based on levels of 4-PA, PLP and vitamin B6 metabolic rate (4-PA/PLP) by high-performance liquid chromatography. The weighted univariate and multivariate logistics regression models were adopted to explore the association between vitamin B6 status with and the odds of eczema in children and adolescents, with odds ratio (ORs) and 95% confidence intervals (CIs). The subgroup analysis based on age, gender, atopy and body mass index (BMI) were further performed to explore whether the association between vitamin B6 status and eczema in children and adolescents remains robust.
A total of 2,256 eligible children and adolescents were included for further analysis, with the mean aged of 11.81 (±0.09) years old. Among them, 247 (10.95%) had eczema. After adjusted all covariates, we observed high 4-PA was associated with high odds of eczema (OR = 1.57, 95%CI: 1.01-2.44, = 0.044). High 4-PA/PLP was associated with high odds of eczema (OR = 1.46, 95%CI: 1.05-2.03, = 0.028); however, no significant associations were found between dietary vitamin B6 intake and serum PLP level (all > 0.05). The results of subgroup analysis shown that the association between 4-PA and 4-PA/PLP remain robust, especially among children and adolescents aged 6-11 years old, boys, with atopy, and with overweight/obese.
Our study observed that high 4-PA and high vitamin B6 metabolic rate were associated with increased odds of eczema in children and adolescents. Maintaining high vitamin level may have potential benefits in reducing odds for eczema in children and adolescents.
很少有研究调查儿童和青少年维生素B6状态与湿疹几率之间的关系。因此，本研究旨在探讨儿童和青少年维生素B6状态与湿疹之间的关联。
基于2005 - 2006年国家健康与营养检查调查（NHANES）进行横断面研究。通过高效液相色谱法，根据4 - 磷酸吡哆醛（4 - PA）、磷酸吡哆醛（PLP）水平和维生素B6代谢率（4 - PA/PLP）评估维生素B6状态。采用加权单因素和多因素逻辑回归模型，以比值比（OR）和95%置信区间（CI）探讨儿童和青少年维生素B6状态与湿疹几率之间的关联。进一步进行基于年龄、性别、特应性和体重指数（BMI）的亚组分析，以探讨儿童和青少年维生素B6状态与湿疹之间的关联是否仍然显著。
共纳入2256名符合条件的儿童和青少年进行进一步分析，平均年龄为11.81（±0.09）岁。其中，247名（10.95%）患有湿疹。调整所有协变量后，我们观察到高4 - PA与高湿疹几率相关（OR = 1.57，95%CI：1.01 - 2.44，P = 0.044）。高4 - PA/PLP与高湿疹几率相关（OR = 1.46，95%CI：1.05 - 2.03，P = 0.028）；然而，饮食中维生素B6摄入量与血清PLP水平之间未发现显著关联（所有P>0.05）。亚组分析结果表明，4 - PA与4 - PA/PLP之间的关联仍然显著，尤其是在6 - 11岁的儿童和青少年、男孩、患有特应性疾病以及超重/肥胖的人群中。
我们的研究观察到，高4 - PA和高维生素B6代谢率与儿童和青少年湿疹几率增加相关。维持高维生素水平可能对降低儿童和青少年湿疹几率有潜在益处。
