Case series demonstrating the effectiveness of Zn supplements in adults with hypophosphatasia who were overlooked for a long time.

During routine medical examinations, we incidentally diagnosed 11 individuals with hypophosphatasia, which is a condition that has previously gone unrecognized. Six patients also had low levels of serum Zn. Supplemental Zn treatment was effective in controlling the symptoms of hypophosphatasia in all patients. One patient complained of muscle pain and twitching after starting Zn supplement treatment temporarily. The subjected three patients in whom Zn supplements were effective showed improvements in bone mineral density and general malaise. Zn supplements might be useful for controlling symptoms in patients with hypophosphatasia who have mild symptoms.