Sharma Kirti, Parashar Bhupesh, Wernicke A Gabriella
Radiation, Virginia Commonwealth University, Richmond, USA.
Radiation Oncology, Northwell Health, New Hyde Park, USA.
Cureus. 2025 Jul 25;17(7):e88735. doi: 10.7759/cureus.88735. eCollection 2025 Jul.
Radiation recall dermatitis (RRD) is a rare phenomenon. There are a few reports in the literature reporting RRD triggered by quinolone administration after external beam radiation therapy (EBRT). We present an unusual case of RRD induced by cefadroxil, which occurred months after completion of EBRT. A patient underwent accelerated partial breast irradiation (APBI) to the right breast, which she finished without any side effects to the skin. She then underwent a left hip replacement and was placed on an antibiotic called cefadroxil 500 mg BID (twice a day), which correlated with a sudden redness in the right breast. The antibiotic was stopped, and her affected breast was treated with clobetasol cream 0.05%, and the patient's RRD resolved. We review literature emphasizing cefadroxil antibiotic as a causative agent of RRD.
放射性回忆性皮炎（RRD）是一种罕见现象。文献中有一些报道称，在体外放射治疗（EBRT）后，喹诺酮类药物的使用引发了RRD。我们报告一例由头孢羟氨苄引起的不寻常RRD病例，该病例发生在EBRT结束数月后。一名患者接受了右侧乳房的加速部分乳腺照射（APBI），照射结束时皮肤未出现任何副作用。随后她接受了左髋关节置换手术，并开始服用一种名为头孢羟氨苄的抗生素，剂量为每日两次，每次500毫克，之后右侧乳房突然出现发红。停用抗生素后，对她受影响的乳房使用0.05%的氯倍他索乳膏进行治疗，患者的RRD症状得到缓解。我们回顾了强调头孢羟氨苄抗生素作为RRD致病因素的文献。
