Yang Yu, Cao Jinfeng, Lyu Jie
College of Rehabilitation Sciences, Shanghai University of Medicine and Health Sciences, Shanghai, China.
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Front Nutr. 2025 Jul 11;12:1560617. doi: 10.3389/fnut.2025.1599601. eCollection 2025.
Cardiovascular disease (CVD) is a major global health issue. The triglyceride-glucose (TyG) index, a marker of insulin resistance, and the body roundness index (BRI), reflecting visceral adiposity, are key risk factors for chronic diseases. However, research on the long-term impact of changes in obesity and metabolic markers on CVD risk is limited. This study examines the association between long-term changes in the TyG-BRI composite index and CVD incidence in middle-aged and older Chinese adults.
Data were obtained from the China Health and Retirement Longitudinal Study, which included 4,446 middle-aged and elderly from 2011 to 2015. The participants were classified into three clusters based on TyG-BRI changes by K-means clustering method. Logistic regression analyses and restricted cubic spline (RCS) regression analyses were used to assess the association between the TyG-BRI and CVD incidence. Receiver operating characteristic (ROC) curves were generated to compare the predictive accuracy of the TyG-BRI, TyG, and BRI.
By the end of 2015, 1,007 participants (22.6%) had developed CVD. The incidence of CVD increased progressively across TyG-BRI clusters. After adjusting for multiple covariates, logistic regression analysis revealed a significant correlation between the TyG-BRI and the onset of CVD [odds ratio, 95% confidence interval: 1.251 (1.139-1.373) per 1 SD increase]. The RCS regression analysis revealed a significant positive and linear relationship between the TyG-BRI and CVD incidence ( for overall < 0.001, for nonlinear = 0.874). ROC analysis revealed that the TyG-BRI had greater predictive accuracy for CVD than either BRI or TyG alone did (AUC: 0.678 vs. 0.583 and 0.555, < 0.001).
Long-term variations in the TyG-BRI index are closely associated with CVD risk, demonstrating superior predictive performance compared to using BRI or TyG alone. Our findings offer new insights into the interplay between metabolic dysfunction and cardiovascular risk. TyG-BRI may serve as a more effective auxiliary tool for CVD risk assessment and provides valuable guidance for the early identification of high-risk populations.
心血管疾病（CVD）是一个重大的全球健康问题。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的一个标志物，而身体圆润度指数（BRI）反映内脏脂肪，是慢性疾病的关键危险因素。然而，关于肥胖和代谢标志物变化对心血管疾病风险的长期影响的研究有限。本研究探讨了TyG-BRI综合指数的长期变化与中国中老年成年人心血管疾病发病率之间的关联。
数据来自中国健康与养老追踪调查，该调查涵盖了2011年至2015年的4446名中老年人。通过K均值聚类方法，根据TyG-BRI变化将参与者分为三个类别。采用逻辑回归分析和受限立方样条（RCS）回归分析来评估TyG-BRI与心血管疾病发病率之间的关联。生成受试者工作特征（ROC）曲线以比较TyG-BRI、TyG和BRI的预测准确性。
到2015年底，1007名参与者（22.6%）发生了心血管疾病。心血管疾病的发病率在TyG-BRI类别中逐渐增加。在调整多个协变量后，逻辑回归分析显示TyG-BRI与心血管疾病的发病之间存在显著相关性[比值比，95%置信区间：每增加1个标准差为1.251（1.139 - 1.373）]。RCS回归分析显示TyG-BRI与心血管疾病发病率之间存在显著的正线性关系（总体P < 0.001，非线性P = 0.874）。ROC分析显示，TyG-BRI对心血管疾病的预测准确性高于单独的BRI或TyG（AUC：0.678对0.583和0.555，P < 0.001）。
TyG-BRI指数的长期变化与心血管疾病风险密切相关，与单独使用BRI或TyG相比，具有更好的预测性能。我们的研究结果为代谢功能障碍与心血管风险之间的相互作用提供了新的见解。TyG-BRI可作为心血管疾病风险评估更有效的辅助工具，并为高危人群的早期识别提供有价值的指导。
