Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Deputy Director of Research and Preventive Cardiology, National Medical Research Centre of Cardiology named after E. Chazov, Moscow, Russia; Head of Evidence-Based Medicine Department, Institute of Medicine, Peoples' Friendship University of Russia (RUDN), Moscow, Russia.
Int J Cardiol. 2025 Jan 1;418:132663. doi: 10.1016/j.ijcard.2024.132663. Epub 2024 Oct 18.
In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG.
在肥胖症和糖尿病等代谢性疾病发病率不断上升的时期，医疗保健专业人员面临着重大挑战。因此，对胰岛素抵抗进行准确的全球评估至关重要。目前的医学研究集中于寻找一种易于获取且可重复的胰岛素抵抗的金标准替代标志物。理想情况下，这样的标志物能够使医疗保健提供者预测 2 型糖尿病和心血管疾病的风险。甘油三酯-葡萄糖指数（TyG）是预防心脏病学和心脏代谢医学有前途的标志物。本综述性文章旨在全面评估 TyG 作为心脏代谢连续体不同阶段患者胰岛素抵抗替代标志物的可信度。这种评估完全符合循证医学，并为 TyG 的临床实用性提供了有价值的见解。
