Clemente-Suárez Vicente Javier, Rey-Mota Jorge, Escribano-Colmena Guillermo, Marín Noelia Vanessa, Fernandez-Lucas Jesús
Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Villaviciosa de Odón, 28670 Madrid, Spain.
Grupo de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, tlantico, Colombia.
Sex Med. 2025 Jul 27;13(3):qfaf046. doi: 10.1093/sexmed/qfaf046. eCollection 2025 Jun.
Premature ejaculation (PE) is a common male sexual dysfunction with limited long-term therapeutic options. Pharmacological and behavioral treatments often yield only temporary improvement, and alternative neuromodulatory strategies remain underexplored. Functional neurology, which targets autonomic and sensory-motor regulation, may offer a novel approach.
To evaluate the effect of a single functional neurology intervention on genital thermoregulation and ejaculatory latency in men with PE.
Fifty-two men diagnosed with PE participated in a pre-post intervention study. Each underwent a single session of functional neurology aimed at modulating nociceptor and mechanoreceptor pathways. Genital thermoregulation was assessed using infrared thermography, and ejaculatory function was measured via intravaginal ejaculatory latency time (IELT) and self-report at baseline, after the first post-treatment sexual encounter, and at 1-month follow-up. Statistical analyses included repeated-measures ANOVA, paired -tests, Pearson correlation, and multiple regression.
Significant improvements in IELT and genital temperature were expected following the intervention, supporting its role in enhancing autonomic regulation and microvascular circulation.
Intravaginal ejaculatory latency time increased significantly from a baseline of 20.4 ± 11.5 seconds to 439.2 ± 214.5 seconds post-treatment, with sustained effects at 1 month (498.0 ± 171.6 seconds; < .001). Infrared thermography revealed significant increases in temperature in the glans, testicles, and abdomen (all < .001), indicating enhanced peripheral circulation. Glans temperature change was the strongest predictor of testicular thermoregulation (β = 0.513, < .001). Principal component analysis highlighted that glans and testicular areas contributed most to thermal variance post-treatment. A ≥1 °C increase in genital temperature was observed in 60% of participants.
Functional neurology may be a non-invasive, fast-acting intervention for improving ejaculatory control in PE by promoting autonomic balance and vascular function. Thermography proved useful as a biomarker for physiological changes and treatment efficacy.
This study is the first to evaluate thermographic and ejaculatory outcomes after a functional neurology intervention in PE. Strengths include objective and subjective measures, while limitations involve the lack of a control group, small sample size, and short-term follow-up. These results should be confirmed through randomized controlled trials.
A single session of functional neurology significantly improved both genital thermoregulation and ejaculatory latency in men with PE. These findings support the integration of neuromodulatory techniques into multidisciplinary strategies for sexual dysfunction treatment.
早泄（PE）是一种常见的男性性功能障碍，长期治疗选择有限。药物和行为治疗通常只能带来暂时的改善，而替代性神经调节策略仍未得到充分探索。针对自主神经和感觉运动调节的功能神经学可能提供一种新方法。
评估单次功能神经学干预对早泄男性生殖器温度调节和射精潜伏期的影响。
52名被诊断为早泄的男性参与了一项干预前后的研究。每人接受了一次旨在调节伤害感受器和机械感受器通路的功能神经学治疗。使用红外热成像评估生殖器温度调节，并通过阴道内射精潜伏期时间（IELT）和基线时、首次治疗后性接触后以及1个月随访时的自我报告来测量射精功能。统计分析包括重复测量方差分析、配对t检验、Pearson相关性分析和多元回归分析。
干预后预期IELT和生殖器温度会有显著改善，这支持了其在增强自主神经调节和微血管循环中的作用。
阴道内射精潜伏期时间从基线时的20.4±11.5秒显著增加至治疗后的439.2±214.5秒，在1个月时仍有持续效果（498.0±171.6秒；P<0.001）。红外热成像显示龟头、睾丸和腹部温度显著升高（均P<0.001），表明外周循环增强。龟头温度变化是睾丸温度调节的最强预测因素（β=0.513，P<0.001）。主成分分析突出显示，治疗后龟头和睾丸区域对热变化的贡献最大。60%的参与者生殖器温度升高≥1°C。
功能神经学可能是一种通过促进自主神经平衡和血管功能来改善早泄射精控制的非侵入性、快速起效的干预措施。热成像被证明是生理变化和治疗效果的有用生物标志物。
本研究是首次评估功能神经学干预早泄后的热成像和射精结果。优点包括客观和主观测量，而局限性包括缺乏对照组、样本量小和短期随访。这些结果应通过随机对照试验来证实。
单次功能神经学治疗显著改善了早泄男性的生殖器温度调节和射精潜伏期。这些发现支持将神经调节技术整合到性功能障碍治疗的多学科策略中。
