影响范围：抗真菌耐受性和持续性的诊断
mSphere of Influence: Diagnosis of antifungal tolerance and persistence.
作者信息
Chen Lei
机构信息
Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China.
出版信息
mSphere. 2025 Aug 26;10(8):e0002925. doi: 10.1128/msphere.00029-25. Epub 2025 Jul 28.
Lei Chen works in the field of clinical diagnosis of antifungal tolerance and persistence. In this mSphere of Influence, he reflects on how the papers "Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia" by A. Rosenberg, I. V. Ene, M. Bibi, S. Zakin, et al. (Nat Commun 9:2470, 2018, https://doi.org/10.1038/s41467-018-04926-x) and "Macrophage internalization creates a multidrug-tolerant fungal persister reservoir and facilitates the emergence of drug resistance" by A. Arastehfar, F. Daneshnia, N. Cabrera, S. Penalva-Lopez, et al. (Nat Commun 14:1183, 2023, https://doi.org/10.1038/s41467-023-36882-6) impacted his work on the development of diagnostic methods for antifungal tolerance and persistence.
陈雷从事抗真菌耐受性和持续性的临床诊断领域的工作。在本期“影响范围”专栏中，他反思了A. 罗森伯格、I. V. 埃内、M. 比比、S. 扎金等人发表的论文《抗真菌耐受性是一种与耐药性不同的亚群效应，与持续性念珠菌血症相关》（《自然通讯》9:2470，2018年，https://doi.org/10.1038/s41467-018-04926-x）以及A. 阿拉斯泰法尔、F. 达内什尼亚、N. 卡布雷拉、S. 佩纳尔瓦-洛佩斯等人发表的论文《巨噬细胞内化形成多药耐受性真菌持留菌库并促进耐药性的出现》（《自然通讯》14:1183，2023年，https://doi.org/10.1038/s41467-023-36882-6）如何影响他在抗真菌耐受性和持续性诊断方法开发方面的工作。
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