Imandar Mohsen, Javadi Amir, Abdollahpour Gholamreza, Mahale Parisa Rahimi Siahkal, Qanbari Alireza, Mirzaalimohammadi Mostafa, Taherkhani Eshagh, Olfatifar Meysam, Nikkhahi Farhad, Eslahi Aida Vafae, Badri Milad
Qazvin Province Directorate of Iran Veterinary Organization, Qazvin, Iran.
Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Vet Med Sci. 2025 Sep;11(5):e70520. doi: 10.1002/vms3.70520.
Leptospirosis, a global zoonotic disease caused by pathogenic Leptospira spp., poses significant health risks to both animals and humans. This study aimed to assess the seroprevalence of antibodies against Leptospira interrogans serovars in stabled horses in Qazvin province, Northwest Iran. From January 2023 to April 2024, a total of 83 blood samples were collected from asymptomatic horses using the microscopic agglutination test (MAT). Results indicated a seroprevalence of 40.96% (95% CI: 31-52), with notable variations among regions: 38.89% (95% CI: 27-52) in Qazvin, 38.46% (95% CI: 18-64) in Alborz and 50% (95% CI: 28-72) in Takestan. The Hardjo serovar was most prevalent (21.68%, 95% CI: 14-32), followed by Icterohaemorrhagiae (13.25%, 95% CI: 7-22) and Canicola (7.22%, 95% CI: 3-15). Statistical analysis revealed significant associations between seropositivity and factors such as the presence of domestic animals and housing conditions. Notably, adult horses exhibited higher seropositivity compared to younger ones. This study highlights the potential role of horses as reservoirs for Leptospira, particularly the Hardjo serovar, suggesting a zoonotic risk to humans and underscoring the need for effective surveillance and control measures in equine populations.
钩端螺旋体病是一种由致病性钩端螺旋体属细菌引起的全球性人畜共患病，对动物和人类都构成重大健康风险。本研究旨在评估伊朗西北部加兹温省圈养马匹中抗问号钩端螺旋体血清型抗体的血清流行率。从2023年1月至2024年4月，使用显微镜凝集试验（MAT）从无症状马匹中总共采集了83份血样。结果显示血清流行率为40.96%（95%置信区间：31-52），各地区存在显著差异：加兹温为38.89%（95%置信区间：27-52），阿尔伯兹为38.46%（95%置信区间：18-64），塔克斯坦为50%（95%置信区间：28-72）。哈德乔血清型最为普遍（21.68%，95%置信区间：14-32），其次是出血性黄疸型（13.25%，95%置信区间：7-22）和犬型（7.22%，95%置信区间：3-15）。统计分析显示血清阳性与家畜存在和住房条件等因素之间存在显著关联。值得注意的是，成年马的血清阳性率高于年轻马。本研究强调了马匹作为钩端螺旋体宿主的潜在作用，特别是哈德乔血清型，表明对人类存在人畜共患病风险，并强调了对马群采取有效监测和控制措施的必要性。
