Zhao Ruojin, Wang Weijing, Liu Yanxiang, Dun Yaojun, Zhang Bowen, Wang Luchen, Zhou Sangyu, Sun Xiaogang
Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Department of Neurology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
Interdiscip Cardiovasc Thorac Surg. 2025 Aug 5;40(8). doi: 10.1093/icvts/ivaf179.
To evaluate the early and late outcomes of the redo procedure for total arch replacement following previous cardiovascular surgery.
Between January 2013 and November 2023, 117 patients underwent total aortic arch replacement after previous cardiovascular surgery in our centre. Surgical indication, perioperative data, postoperative complications, and late outcomes were retrospectively analysed.
The mean age of patients was 46.8 ± 13.0 years, and 32 were female (27.4%). Indications for redo procedure included aortic arch aneurysm (11, 9.4%), aneurysmal expansion of a chronic dissection (35, 29.9%), staged surgery in plan (3, 2.6%), aortitis (2, 1.7%), and iatrogenic reasons (16, 13.7%). In-hospital mortality was 6.8% with 13.7% major adverse events. Patients who received bilateral cerebral perfusion had significantly higher intraoperative temperatures [nasopharyngeal: 23.4°C (20.4°C-25.0°C) vs 26.8°C (25.0°C-27.5°C), P < .001; bladder: 25.5 ± 3.2°C vs 28.8 ± 1.8°C, P < .001] and required fewer platelet transfusions [median units: 1.0 (1.0-2.0) vs 1.00 (1.0-1.0), P = .003], with no significant differences in postoperative neurological deficits. Overall survival of the patients was 90.1% [95% confidence interval (CI): 84.2%-96.5%], 86.9% (95% CI: 79.8%-94.6%), and 80.0% (95% CI: 70.5%-90.8%) at 1, 3, and 5 years, respectively. During follow-up, 14 patients received aortic-related reintervention. The cumulative incidence of reintervention was 17.20% (95% CI: 7.22%-26.11%) at 5 years.
Although redo total arch replacement is technically challenging, acceptable early and late results can be obtained through tailored surgical planning and end-organ protection.
评估既往心血管手术后再次进行全弓置换手术的早期和晚期结果。
2013年1月至2023年11月期间,117例患者在本中心接受了既往心血管手术后的全主动脉弓置换术。对手术指征、围手术期数据、术后并发症和晚期结果进行回顾性分析。
患者的平均年龄为46.8±13.0岁,女性32例(27.4%)。再次手术的指征包括主动脉弓瘤(11例,9.4%)、慢性夹层动脉瘤样扩张(35例,29.9%)、计划性分期手术(3例,2.6%)、主动脉炎(2例,1.7%)和医源性原因(16例,13.7%)。住院死亡率为6.8%,主要不良事件发生率为13.7%。接受双侧脑灌注的患者术中体温显著更高[鼻咽部:23.4°C(20.4°C - 25.0°C)对26.8°C(25.0°C - 27.5°C),P <.001;膀胱:25.5±3.2°C对28.8±1.8°C,P <.001],且所需血小板输注较少[中位数单位:1.0(1.0 - 2.0)对1.00(1.0 - 1.0),P =.003],术后神经功能缺损无显著差异。患者的1年、3年和5年总生存率分别为90.1%[95%置信区间(CI):84.2% - 96.5%]、86.9%(95% CI:79.8% - 94.6%)和80.0%(95% CI:70.5% - 90.8%)。随访期间,14例患者接受了主动脉相关的再次干预。5年时再次干预的累积发生率为17.20%(95% CI:7.22% - 26.11%)。
尽管再次全弓置换手术在技术上具有挑战性,但通过量身定制的手术规划和终末器官保护可获得可接受的早期和晚期结果。