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急性A型主动脉夹层修复术后二次主动脉手术的适应症及结果

Indications and outcomes of second aortic procedures after acute type A dissection repair.

作者信息

Morjan Mohammed, Mestres Carlos-A, Savic Vedran, Gerçek Mustafa, Van Hemelrijck Mathias, Sromicki Juri, Dzemali Omer, Reser Diana

机构信息

Department of Cardiac Surgery, University Hospital Zürich, Zürich, Switzerland.

Department of Cardiovascular Surgery, Heinrich Heine University, Medical Faculty, Duesseldorf, Germany.

出版信息

Interdiscip Cardiovasc Thorac Surg. 2024 May 3;38(5). doi: 10.1093/icvts/ivae076.

Abstract

OBJECTIVES

Aortic arch or aortic root replacement is not performed in all cases of acute type A aortic dissection (ATAD), and a second aortic procedure will become necessary over time for some patients. Indications and outcomes, of second aortic procedures have not been studied extensively.

METHODS

Characteristics and in-hospital outcomes of all patients undergoing surgical repair for type A acute aortic dissection were analysed and patients needing second aortic procedure during follow-up were identified. The latter group was divided in 2 subgroups: on-pump includes patients operated on using cardiopulmonary bypass and off-pump without cardiopulmonary bypass.

RESULTS

A total of 638 patients underwent surgery for ATAD; 8% required a second aortic procedure. The most frequent indication for the second aortic procedure was dehiscence of suture lines (44%), followed by arch dilatation (24%). In-hospital mortality was 12%. Isolated ascending aorta replacement at the first surgery was associated with higher incidence of second aortic procedure (P = 0.006). Most patients in the on-pump group underwent a proximal reoperation (75%), with a mortality rate of 14.2%. In-hospital mortality of patients in the off-pump group was 7.7%. Long-term survival analysis showed no difference between groups (P = 0,526), Off-pump patients have greater likelihood of a second intervention during follow-up (P  = 0.004).

CONCLUSIONS

Extended aortic root surgery and customized aortic arch repair in ATAD could be reasonable to reduce the incidence and mortality of high-risk second aortic procedures.

摘要

目的

并非所有急性A型主动脉夹层(ATAD)病例都需要进行主动脉弓或主动脉根部置换术,随着时间的推移,一些患者将需要进行第二次主动脉手术。第二次主动脉手术的适应症和结果尚未得到广泛研究。

方法

分析所有接受A型急性主动脉夹层手术修复患者的特征和住院结局,并确定随访期间需要进行第二次主动脉手术的患者。后一组患者分为两个亚组:体外循环组包括使用体外循环进行手术的患者,非体外循环组则是不使用体外循环的患者。

结果

共有638例患者接受了ATAD手术;8%的患者需要进行第二次主动脉手术。第二次主动脉手术最常见的适应症是缝线裂开(44%),其次是主动脉弓扩张(24%)。住院死亡率为12%。首次手术时单纯升主动脉置换与第二次主动脉手术的发生率较高相关(P = 0.006)。体外循环组的大多数患者进行了近端再次手术(75%),死亡率为14.2%。非体外循环组患者的住院死亡率为7.7%。长期生存分析显示两组之间无差异(P = 0.526),非体外循环患者在随访期间进行第二次干预的可能性更大(P = 0.004)。

结论

在ATAD中进行扩大的主动脉根部手术和定制的主动脉弓修复可能是合理的,以降低高风险第二次主动脉手术的发生率和死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a296/11090986/c56ab85e7ebb/ivae076f2.jpg

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