Riahi Parisa, Teymoori Farshad, Farhadnejad Hossein, Zarkesh Maryam, Zahedi Asiyeh Sadat, Rashidi Mahtab, Roudbar Mahmoud Amiri, Habibi Danial, Masoudi Homayoon, Mirmiran Parvin, Majidpour Fatemeh, Jahangiri Mina, Saeidian Amir Hesam, Barzin Maryam, Hosseinpanah Farhad, Daneshpour Maryam S, Akbarzadeh Mahdi
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, 19395-4763, Tehran, Iran.
Nutritional Sciences Research Center, Iran University of Medical Sciences, Tehran, Iran.
Behav Genet. 2025 Jul 28. doi: 10.1007/s10519-025-10228-y.
Asian residents frequently have a higher percentage of body fat in comparison to individuals with European ancestry, which increases their susceptibility to metabolic diseases. This study aimed to explore the familial resemblance patterns of different body adiposity indicators among 16,983 Tehranian adults. The intraclass correlation coefficients (ICC) of first-degree pairs were estimated to verify the family resemblance of the anthropometric and adiposity-related traits(ARTs) between family members and spouses. The family-based heritability of ARTs was estimated using the classical likelihood-based approach. Results were obtained based upon two scenarios: the first measurement scenario(FM), analysis of the individuals' ARTs in which they become ≥ 18 years for the first time, and the second scenario, which was based on the average of valid values of the ARTs for each individual(AM). There were 22,879 first-degree relative pairs (17,562 Parents/offspring and 5,137 siblings), 11,015 s-degree relative pairs, and 1,299 third-degree cousin pairs. The familial resemblance between sibling pairs of the same sex was significantly higher than those of other pairs, as for brother: brother pairs, ICC ranged between 19.6% (95%CI:0.118,0.274) for a body shape index(ABSI) to 35.6% (95%CI:0.280,0.432) for body mass index(BMI). Also, for sister: sister pairs, ICC varied from 19.4% (95%CI:0.116,0.272)(ABSI) to 36.6% (95%CI:0.280,0.432)(BMI). For spouses, ICC varied between 5.6% (95%CI:0.025,0.087) for waist-to-hip ratio(WHR) to 10.4% (95%CI:0.065,0.143) for waist circumference. Family-based heritability estimation ranged from 28% (SE = 0.026) for body adiposity index (BAI) to 43% (SE = 0.024) for BMI. The highest pairwise correlation between family members was shown to exist between siblings, and same-sex relative pairs have shown a relatively larger correlation than relative pairs with a different sex.
与欧洲血统的人相比，亚洲居民的体脂百分比通常更高，这增加了他们患代谢性疾病的易感性。本研究旨在探讨16983名德黑兰成年人中不同身体肥胖指标的家族相似模式。估计一级亲属对的组内相关系数（ICC），以验证家庭成员和配偶之间人体测量和肥胖相关特征（ARTs）的家族相似性。使用基于经典似然法估计ARTs的家族遗传度。结果基于两种情况获得：第一种测量情况（FM），分析个体首次年满≥18岁时的ARTs，第二种情况基于每个个体ARTs有效值的平均值（AM）。有22879对一级亲属（17562对父母/子女和5137对兄弟姐妹）、11015对二级亲属和1299对三级堂亲。同性兄弟姐妹对之间的家族相似性显著高于其他对，对于兄弟对，身体形状指数（ABSI）的ICC在19.6%（95%CI：0.118，0.274）至体重指数（BMI）的35.6%（95%CI：0.280，0.432）之间。同样，对于姐妹对，ICC从19.4%（95%CI：0.116，0.272）（ABSI）到36.6%（95%CI：0.280，0.432）（BMI）不等。对于配偶，腰臀比（WHR）的ICC在5.6%（95%CI：0.025，0.087）至腰围的10.4%（95%CI：0.065，0.143）之间。基于家族的遗传度估计范围从身体肥胖指数（BAI）的28%（SE = 0.026）到BMI的43%（SE = 0.024）。家庭成员之间最高的成对相关性显示存在于兄弟姐妹之间，同性亲属对比异性亲属对显示出相对更大的相关性。
