Li M T, Zhang M N, Zhi X Y, Zhu H, Zhang X, Xie J
School of Public Health, Tianjin Medical University, Tianjin 300070, China.
School of Public Health, Tianjin Medical University, Tianjin 300070, China Tianjin Key Laboratory of Environment, Nutrition & Public Health, Tianjin 300070, China Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin 300070, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Dec 10;42(12):2188-2195. doi: 10.3760/cma.j.cn112338-20210310-00193.
To use Meta analysis to understand the prevalence of the heritability of body mass index (BMI) in twins. All studies on the heritability of the twins' BMI published before December 31, 2020 were retrieved through the China National Knowledge Network, Wanfang, VIP, PubMed and Web of Science databases. The literature quality was evaluated by using Joanna Briggs Institute Critical Appraisal tools. Stata 16.0 was used to perform subgroup analysis on the outcome indicators (heritability, 95%) to explore the source of heterogeneity. The local weighted regression method was used to fit the trend of heritability with age. The publication bias test and the sensitivity analysis of included literatures were also performed by using Stata 16.0. A total of 10 articles meeting the inclusion and exclusion criteria were included with 79 twins' independent estimates of heritability for BMI. Meta-analysis showed that the combined value of BMI heritability was 0.69 (95%: 0.65-0.71), the combined value of BMI (0.68, 95%: 0.65-0.70) in males was lower than that (0.70, 95%: 0.68-0.72) in females. The heritability of BMI (0.72, 95%: 0.68-0.76) in childhood and adolescence was higher than that (0.68, 95%: 0.66-0.70) in adulthood. The gender specific difference in BMI heritability in twins ≤18 years old was even greater, which was lower in males (0.68, 95%: 0.61-0.76) than in females (0.75, 95%: 0.69-0.81). The heritability increased with age in childhood, reached peak at about 18 years old, and then slowly decreased with age. The heritability of BMI varied with population characteristics, especially age and gender. In view of the high estimated value of BMI heritability in female children and adolescents, more attention should be paid to the start time of health intervention.
运用Meta分析了解双胞胎体重指数（BMI）遗传度的流行情况。通过中国知网、万方、维普、PubMed及Web of Science数据库检索2020年12月31日前发表的关于双胞胎BMI遗传度的所有研究。采用乔安娜·布里格斯研究所的批判性评价工具评估文献质量。运用Stata 16.0对结局指标（遗传度，95%）进行亚组分析，以探究异质性来源。采用局部加权回归法拟合遗传度随年龄的变化趋势。还使用Stata 16.0进行发表偏倚检验及纳入文献的敏感性分析。共纳入10篇符合纳入和排除标准的文章，其中有79对双胞胎对BMI遗传度的独立估计值。Meta分析显示，BMI遗传度的合并值为0.69（95%：0.65 - 0.71），男性BMI的合并值（0.68，95%：0.65 - 0.70）低于女性（0.70, 95%：0.68 - 0.72）。儿童和青少年时期BMI的遗传度（0.72，95%：0.68 - 0.76）高于成年期（0.68，95%：0.66 - 0.70）。18岁及以下双胞胎中，BMI遗传度的性别差异更大，男性（0.68，95%：0.61 - 0.76）低于女性（0.75，95%：0.69 - 0.81）。儿童期遗传度随年龄增加，在18岁左右达到峰值，随后随年龄缓慢下降。BMI的遗传度随人群特征而变化，尤其是年龄和性别。鉴于女童和青少年中BMI遗传度的估计值较高，应更加关注健康干预的起始时间。
