Matsuda Sei, Kuwajima Yukinori, Nishijima Tsuguo, Yoshida Hironori, Sakurai Naoto, Yamaguchi Takayuki, Hosokawa Keisuke, Mineta Takenori, Izumisawa Mitsuru, Satoh Kazuro
Division of Orthodontics, Department of Developmental Oral Health Science, School of Dentistry, Iwate Medical University, Morioka, Japan.
Division of Behavioral Sleep Medicine, Iwate Medical University School of Medicine, Morioka, Japan.
Metab Syndr Relat Disord. 2025 Sep;23(7):349-356. doi: 10.1177/15578518251363192. Epub 2025 Jul 29.
Obesity is the most important factor in obstructive sleep apnea (OSA). Even if metabolic surgery (MS) weight loss is achieved, the therapeutic effect has not been proven for OSA. This study compared the apnea-hypopnea index (AHI) before surgery (T0), 1 year after surgery (T1), and 2 years after surgery (T2), assuming that the effect of MS on the AHI is influenced by the ANB angle (formed by point A, nasion, and point B), which reflects the anteroposterior relationship between the maxilla and mandible. The study included 47 patients with a body mass index ≥35 kg/m who underwent MS. To compare the AHI before and after surgery, we classified participants into three groups based on the ANB angle at the initial examination: skeletal Class I (>1° and <4°), II (≥4°), and III (≤1°). The mean AHI of all participants was 56.8 events/hr at T0, 26.5 at T1, and 23.7 at T2. Both postsurgical values were significantly lower than the presurgical value at T0. The mean AHI in skeletal Class I was 19.1 at T1 and 15.1 at T2, which was a significant decrease compared with T0 (50.4). Although the mean AHI was 38.8 at T1 and 38.8 at T2 in the skeletal Class II, which were lower than that at T0 (65.9), no significant difference was observed. The mean AHI was 20.0 at T1 and 15.3 at T2 in the skeletal Class III, which were significantly decreased as compared with that at T0 (53.5). Measuring the ANB angle prior to surgery is useful for predicting the postoperative effect.
肥胖是阻塞性睡眠呼吸暂停(OSA)最重要的因素。即使代谢手术(MS)实现了体重减轻,其对OSA的治疗效果也尚未得到证实。本研究比较了手术前(T0)、手术后1年(T1)和手术后2年(T2)的呼吸暂停低通气指数(AHI),假设MS对AHI的影响受ANB角(由A点、鼻根点和B点形成)影响,该角反映了上颌骨和下颌骨之间的前后关系。该研究纳入了47例体重指数≥35kg/m²且接受了MS的患者。为了比较手术前后的AHI,我们根据初次检查时的ANB角将参与者分为三组:骨骼I类(>1°且<4°)、II类(≥4°)和III类(≤1°)。所有参与者的平均AHI在T0时为56.8次/小时,在T1时为26.5次/小时,在T...