Shao Shuai, Lv Bingbing, Wang Mei, Zeng Sijia, Wang Shiying, Yang Zisong, Ma Pengda
College of Life Sciences, Northwest A&F University, Yangling, 712100, China.
College of Resources and Environment, ABA Teachers College, Wenchuan, 623002, China.
Plant J. 2025 Jul;123(2):e70358. doi: 10.1111/tpj.70358.
Salvia miltiorrhiza, a perennial plant of the genus Salvia in the family Lamiaceae, is one of the most important traditional Chinese medicinal herbs, renowned for its significant economic and medicinal value. Its application in China dates back to 200 BC, where it has been utilized clinically either as a monotherapy or in combination with other herbal medicines for treating cardiovascular and cerebrovascular diseases, as well as various other ailments. The bioactive constituents of S. miltiorrhiza primarily include lipophilic tanshinones and hydrophilic phenolic acids. Over the past decades, the biosynthetic pathways of tanshinones and phenolic acids have been elucidated. Coupled with the sequencing of its genome, substantial progress has been made in deciphering the biosynthesis and regulatory mechanisms of bioactive compounds in S. miltiorrhiza, including tanshinones, phenolic acids, flavonoids, and prenylated quinones. This review summarizes recent advances in the regulatory mechanisms underlying the biosynthesis of phenolic acids and tanshinones in S. miltiorrhiza, focusing on transcriptional regulation, post-translational modifications, and epigenetic regulation. These insights provide a foundation for enhancing the production of bioactive compounds through biotechnological approaches and advancing pharmacological applications.
丹参是唇形科鼠尾草属的一种多年生植物，是最重要的传统中草药之一，因其具有重要的经济和药用价值而闻名。其在中国的应用可追溯到公元前200年，在临床上它被单独使用或与其他草药联合使用，用于治疗心脑血管疾病以及各种其他疾病。丹参的生物活性成分主要包括亲脂性丹参酮和亲水性酚酸。在过去几十年中，丹参酮和酚酸的生物合成途径已被阐明。随着其基因组测序的完成，在解析丹参中生物活性化合物（包括丹参酮、酚酸、黄酮类化合物和异戊烯基醌）的生物合成和调控机制方面取得了重大进展。本综述总结了丹参中酚酸和丹参酮生物合成调控机制的最新进展，重点关注转录调控、翻译后修饰和表观遗传调控。这些见解为通过生物技术方法提高生物活性化合物的产量和推进药理学应用提供了基础。
