Parmar Kaushikkumar D, Rathod Paresh H, Kalasariya Ravi L, Pandya Mayur J, Patel Mitesh R, Chawla Suchi, Patel Mukesh P
AINP on Pesticide Residues & Contaminants, ICAR Unit-9, AAU, Anand, India.
Agricultural& Horticultural Research Station, AAU, Khambholaj, India.
Biomed Chromatogr. 2025 Sep;39(9):e70174. doi: 10.1002/bmc.70174.
Supervised field trials were conducted to understand the dissipation kinetics of the combination product chlorantraniliprole + abamectin and spirotetramat and its metabolites in pomegranate samples. QuEChERS-based methods were successfully used to analyze these pesticides from pomegranate samples with a correlation coefficient R > 0.99, accuracy 70-120%, and precision RSD ≤ 20% in all cases. The dissipation study showed that all the molecules followed first-order kinetics with half-lives ranging from 7.9 to 13.7 days, from 3.6 to 5.5 days, and from 1.4 to 1.6 days for chlorantraniliprole, abamectin, and spirotetramat, respectively. Dissipation kinetics and half-life were calculated in accordance with the residue definition of these pesticides. A pre-harvest (PHI) interval of 10 days is suggested. Risk assessment showed that the theoretical maximum daily intake (TMDI) was less than the acceptable daily intake (ADI) in all cases, suggesting that these pesticides can be used on pomegranate crops without any significant risk, provided good agricultural practices (GAP) are followed with a PHI of 10 days. Data from the present study can be used by national and international regulatory bodies for establishing maximum residue limits (MRLs) in pomegranate as well as can be extrapolated to establish PHI and MRLs for other berry fruits. However, there is a need to undertake such studies in other berry fruits in the future.
进行了监督田间试验，以了解氯虫苯甲酰胺+阿维菌素和螺虫乙酯及其代谢物在石榴样品中的消解动力学。基于QuEChERS的方法成功用于分析石榴样品中的这些农药，在所有情况下相关系数R>0.99，准确度为70-120%，精密度RSD≤20%。消解研究表明，所有分子均遵循一级动力学，氯虫苯甲酰胺、阿维菌素和螺虫乙酯的半衰期分别为7.9至13.7天、3.6至5.5天和1.4至1.6天。根据这些农药的残留定义计算消解动力学和半衰期。建议收获前（PHI）间隔为10天。风险评估表明，在所有情况下，理论最大日摄入量（TMDI）均低于可接受日摄入量（ADI），这表明只要遵循良好农业规范（GAP）并保持10天的PHI，这些农药可用于石榴作物，而不会有任何重大风险。本研究的数据可供国家和国际监管机构用于确定石榴中的最大残留限量（MRL），也可外推用于确定其他浆果的PHI和MRL。然而未来有必要在其他浆果上开展此类研究。
