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利用全国队列数据和自回归积分移动平均模型评估2019冠状病毒病大流行对精神障碍发病率的影响。

Impact of the COVID-19 pandemic on incidence of psychiatric disorders using nationwide cohort data and ARIMA models.

作者信息

Seo Jun Ho, Lee Myeongjee, Kang Sunghyuk, Kim Se Joo, Jung Inkyung, Kang Jee In

机构信息

Department of Psychiatry, Yonsei University Wonju College of Medicine, Wonju, Korea.

Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.

出版信息

Sci Rep. 2025 Jul 28;15(1):27478. doi: 10.1038/s41598-025-12479-5.

Abstract

The present study aimed to investigate the impact of the COVID-19 pandemic on the incidence rates of psychiatric disorders using nationwide cohort data. A retrospective cohort study was conducted using South Korea's nationwide claims database, covering 1,598,540 patients with new psychiatric diagnoses from January 2017 to June 2021. We calculated incidence rate ratios pre- and during-pandemic and employed the autoregressive integrated moving average (ARIMA) model and interrupted time-series analysis to assess pandemic effects on incidence. Additionally, to determine the immediate impact of the pandemic on the observed incidence rates, we used level changes at the transition point by adopting a transfer function. The incidence rates for overall and most psychiatric disorders during the pandemic increased compared to the pre-pandemic period. However, the increases in incidence rates were due to the previous trend rather than the pandemic's impact. A notable exception was found in the diagnostic category of obsessive-compulsive disorders, which experienced a significant surge in incidence rates beyond what was predicted, indicating a direct pandemic impact. The study underscores that while the COVID-19 pandemic has influenced the incidence rates of psychiatric disorders, the effects vary significantly by disorder. The overall increase in psychiatric disorders aligns with pre-pandemic trends, except for obsessive-compulsive and substance-related disorders. Obsessive-compulsive disorders saw an actual increase in incidence rates, whereas substance-related disorders' decrease could reflect changes in healthcare-seeking behavior. The findings of this study provide valuable insights for public health planning and the development of mental health support systems in anticipation of future global health crises.

摘要

本研究旨在利用全国队列数据调查新冠疫情对精神障碍发病率的影响。我们进行了一项回顾性队列研究,使用韩国全国索赔数据库,涵盖了2017年1月至2021年6月期间1598540例新诊断的精神疾病患者。我们计算了疫情前和疫情期间的发病率比,并采用自回归积分移动平均(ARIMA)模型和中断时间序列分析来评估疫情对发病率的影响。此外,为了确定疫情对观察到的发病率的直接影响,我们采用传递函数,通过转换点的水平变化来进行分析。与疫情前相比,疫情期间总体及大多数精神障碍的发病率有所上升。然而,发病率的上升是由于先前的趋势,而非疫情的影响。一个显著的例外是强迫症诊断类别,其发病率出现了超出预期的显著激增,表明疫情有直接影响。该研究强调,虽然新冠疫情影响了精神障碍的发病率,但不同障碍的影响差异显著。除强迫症和物质相关障碍外,精神障碍的总体增加与疫情前趋势一致。强迫症的发病率实际上升,而物质相关障碍的发病率下降可能反映了就医行为的变化。本研究结果为公共卫生规划以及在应对未来全球健康危机时发展心理健康支持系统提供了宝贵的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ba3/12304157/b9120a0f5876/41598_2025_12479_Fig1_HTML.jpg

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