需要三项研究为超低孕周输血脐带血（U-BET）临床试验的设计提供信息。
Three studies needed to inform the design of the U-BET (umbilical cord blood for extremely low-gestational-age transfusions) clinical trial.
作者信息
Bahr Timothy M, Ohls Robin K, Christensen Thomas R, Monson Martha C, Page Jessica M, Dabling Heather A, Elliott James Cole, Ilstrup Sarah J, Christensen Robert D
机构信息
Obstetric and Neonatal Operations, Intermountain Health, Murray, UT, USA.
Research Department, Intermountain Health, Murray, UT, USA.
出版信息
J Perinatol. 2025 Jul 28. doi: 10.1038/s41372-025-02345-7.
OBJECTIVE
To perform three studies needed to design the "U-BET" trial (Umbilical cord Blood for Extremely-low-gestational-age Transfusions).
STUDY DESIGN
(1) Survey-based self-assessment of Intermountain Health obstetricians regarding drawing umbilical cord blood. (2) Determine the percentage of the potentially donating neonates who have type O blood (to be utilized in U-BET). (3) Quantify cord blood drawn using American Red Cross collection kits.
RESULTS
(1) 72% of respondents declared experience drawing cord blood; 62% with the placenta in utero. (2) Of the past 100,000 women delivering, 48% were type O, and 66% of neonates born to them were type O. (3) The volume of cord blood obtained at 10 births ranged from 20 to 86 mL after the placenta was delivered vs. 14 to157 mL when in utero.
CONCLUSION
The U-BET trial will consent type O women and use Red Cross kits to draw term umbilical cord blood while the placenta is still in utero.
目的
开展三项设计“U-BET”试验（极低孕周输血用脐带血试验）所需的研究。
研究设计
（1）基于调查对山间医疗集团的产科医生进行关于采集脐带血的自我评估。（2）确定具有O型血的潜在捐赠新生儿的比例（用于U-BET试验）。（3）使用美国红十字会采集试剂盒对采集的脐带血进行定量。
结果
（1）72%的受访者宣称有采集脐带血的经验；62%是在胎盘仍在子宫内时进行采集。（2）在过去100,000名分娩的女性中，48%为O型血，其分娩的新生儿中66%为O型血。（3）10例分娩中，胎盘娩出后采集的脐带血体积为20至86毫升，而胎盘在子宫内时采集的脐带血体积为14至157毫升。
结论
U-BET试验将纳入O型血女性，并在胎盘仍在子宫内时使用红十字会试剂盒采集足月脐带血。
Zotero 插件