Balabanski L, Polonov K, Zlateva I, Meretev A
Vutr Boles. 1985;24(4):86-91.
The characteristic signs of Pickwickian syndrome are the high degree of obesity and cardiovascular and respiratory insufficiency, to various degrees. Forty five patients with Pickwickian syndrome were treated at the Clinic of Metabolic Diseases. They represent 3.4 per cent of the total number of patients with obesity of various degrees, observed and treated. The majority of the affected were established to be males (34), mainly III and IV degree of obesity. The average age of the patients was 51 years. Somnolence, lassitude, enhanced appetite, cyanosis and dyspnea with unrestful sleep, with sloring were observed in all patients. The moderate motive regiment applied and the hypoenergy diet under clinical condicions with an average stay of 26 days at the clinic led to considerable reduction of body mass (with 11,7 kg on the average), resulting into an improvement of the functional respiratory parameters and ECG. The elevated values of blood pressure were normalized in the majority of the patients after the treatment. In all patients, the unpleasant subjective complaints, somnolence including, disappeared and respiratory indices were improved. The significant disorders in lipid, carbohydrate and purine metabolism were favourably influenced by the therapeutic regiment applied.
匹克威克综合征的典型体征是高度肥胖以及不同程度的心血管和呼吸功能不全。代谢疾病诊所治疗了45例匹克威克综合征患者。他们占所观察和治疗的不同程度肥胖患者总数的3.4%。大多数患者为男性（34例），主要是III度和IV度肥胖。患者的平均年龄为51岁。所有患者均出现嗜睡、乏力、食欲增强、发绀以及睡眠不安、打鼾伴有的呼吸困难。在临床条件下采用适度运动方案和低能量饮食，患者在诊所平均住院26天，体重显著减轻（平均减轻11.7千克），从而改善了呼吸功能参数和心电图。大多数患者治疗后血压升高值恢复正常。所有患者包括嗜睡在内的不适主观症状消失，呼吸指标得到改善。所采用的治疗方案对脂质、碳水化合物和嘌呤代谢的显著紊乱产生了有利影响。
