Yamada Saeko, Suwa Yuichi, Fujio Keishi
Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Inflamm Regen. 2025 Jul 28;45(1):24. doi: 10.1186/s41232-025-00388-z.
By balancing immunity and tolerance, dendritic cells (DCs) are key regulators of immune responses. Recent studies have highlighted the crucial role of these cells in connective tissue diseases. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) exhibit distinct contributions to disease progression. In systemic lupus erythematosus and systemic sclerosis, pDCs primarily drive pathogenesis via excessive type I interferon production, whereas in rheumatoid arthritis (RA), cDCs play a major role in promoting autoreactive T cell activation. Emerging DC subsets, such as inflammatory DC3s and LAMP3 DCs, have been implicated in RA synovitis. In vasculitis, tissue-resident vascular DCs appear to regulate localized inflammation. Despite advances in single-cell analysis, the functional roles of specific DC subsets remain underexplored in several autoimmune conditions. Understanding DC heterogeneity and function in disease-specific contexts may lead to novel therapeutic strategies targeting DC-mediated immune dysregulation.
通过平衡免疫和耐受，树突状细胞（DCs）是免疫反应的关键调节因子。最近的研究突出了这些细胞在结缔组织疾病中的关键作用。传统树突状细胞（cDCs）和浆细胞样树突状细胞（pDCs）对疾病进展表现出不同的作用。在系统性红斑狼疮和系统性硬化症中，pDCs主要通过过度产生I型干扰素驱动发病机制，而在类风湿关节炎（RA）中，cDCs在促进自身反应性T细胞活化中起主要作用。新兴的DC亚群，如炎性DC3s和LAMP3 DCs，已被认为与RA滑膜炎有关。在血管炎中，组织驻留血管DCs似乎调节局部炎症。尽管单细胞分析取得了进展，但在几种自身免疫性疾病中，特定DC亚群的功能作用仍未得到充分探索。了解疾病特定背景下的DC异质性和功能可能会带来针对DC介导的免疫失调的新型治疗策略。
