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阿尔茨海默病语言缺陷的神经调节干预:当前实践与未来发展的最新情况

Neuromodulation Interventions for Language Deficits in Alzheimer's Disease: Update on Current Practice and Future Developments.

作者信息

Chen Fei, Nie Yuyan, Kuang Chen

机构信息

School of Foreign Languages, Hunan University, Lushannan Road No. 2, Yuelu District, Changsha 410082, China.

出版信息

Brain Sci. 2025 Jul 16;15(7):754. doi: 10.3390/brainsci15070754.

Abstract

Alzheimer's disease (AD) is a leading cause of dementia, characterized by progressive cognitive and language impairments that significantly impact communication and quality of life. Neuromodulation techniques, including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS), have emerged as promising interventions. This study employs bibliometric analysis to evaluate global research trends in neuromodulation treatments for AD-related language impairments. A total of 88 publications from the Web of Science Core Collection (2006-2024) were analyzed using bibliometric methods. Key indicators such as publication trends, citation patterns, collaboration networks, and research themes were examined to map the intellectual landscape of this field. The analysis identified 580 authors across 65 journals, with an average of 34.82 citations per article. Nearly half of the publications were produced after 2021, indicating rapid recent growth. The findings highlight a predominant focus on non-invasive neuromodulation methods, particularly rTMS and tDCS, within neurosciences and neurology. While research activity is increasing, significant challenges persist, including ethical concerns, operational constraints, and the translational gap between research and clinical applications. This study provides insights into the current research landscape and future directions for neuromodulation in AD-related language impairments. The results emphasize the need for novel neuromodulation techniques and interdisciplinary collaboration to enhance therapeutic efficacy and clinical integration.

摘要

阿尔茨海默病(AD)是痴呆症的主要病因,其特征为渐进性认知和语言障碍,对沟通和生活质量产生重大影响。神经调节技术,包括重复经颅磁刺激(rTMS)、经颅直流电刺激(tDCS)和深部脑刺激(DBS),已成为有前景的干预措施。本研究采用文献计量分析来评估针对AD相关语言障碍的神经调节治疗的全球研究趋势。使用文献计量方法对来自科学引文索引核心合集(2006 - 2024年)的88篇出版物进行了分析。研究了诸如出版趋势、引用模式、合作网络和研究主题等关键指标,以描绘该领域的知识版图。分析确定了65种期刊上的580位作者,每篇文章平均被引34.82次。近一半的出版物是在2021年之后发表的,表明近期增长迅速。研究结果突出显示,在神经科学和神经病学领域,主要侧重于非侵入性神经调节方法,特别是rTMS和tDCS。虽然研究活动在增加,但重大挑战依然存在,包括伦理问题、操作限制以及研究与临床应用之间的转化差距。本研究为AD相关语言障碍的神经调节当前研究状况和未来方向提供了见解。结果强调需要新颖的神经调节技术和跨学科合作,以提高治疗效果和临床整合度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26af/12293641/233f3dd384c8/brainsci-15-00754-g001.jpg

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