Trennery P N, Waring R H
Xenobiotica. 1985 Oct;15(10):813-23. doi: 10.3109/00498258509045033.
When either diazepam or imipramine hydrochloride was administered orally to rats with thioacetamide-induced hepatic cirrhosis, the biliary and faecal elimination of metabolites was significantly decreased compared with that in normal animals. However, renal excretion of metabolites of diazepam or imipramine was increased in the liver-damaged rats. Experiments in vitro showed that liver homogenates from cirrhotic rats metabolized diazepam or imipramine hydrochloride in qualitatively and quantitatively similar ways to those from normal rats. Clearance of radioactivity from the blood following i.v. administration of either diazepam or imipramine hydrochloride was prolonged in animals with experimental cirrhosis.
当给硫代乙酰胺诱导的肝硬化大鼠口服地西泮或盐酸丙咪嗪时，与正常动物相比，代谢产物的胆汁和粪便排泄显著减少。然而，肝损伤大鼠中地西泮或丙咪嗪代谢产物的肾排泄增加。体外实验表明，肝硬化大鼠的肝匀浆代谢地西泮或盐酸丙咪嗪的方式在定性和定量上与正常大鼠相似。给实验性肝硬化动物静脉注射地西泮或盐酸丙咪嗪后，血液中放射性的清除时间延长。
