Andrews S M, Griffiths L A
Xenobiotica. 1984 Oct;14(10):751-60. doi: 10.3109/00498258409151473.
The oral administration of [2-14 C]diazepam to streptozotocin (STZ)-diabetic rats resulted in decreased faecal and biliary levels of metabolites with a concomitant rise in urinary radioactivity when compared to control values. This situation was reversible upon insulin treatment. The increased urinary metabolite excretion could not be ascribed to the diuresis observed in STZ-diabetic rats. No alteration in the phase I or II routes of [14C]diazepam metabolism in diabetic animals was observed either in vivo or in vitro. Following i.v. administration of [2-14C]diazepam, blood 14C levels in diabetic rats were elevated above those observed in normal animals.
与对照值相比，给链脲佐菌素（STZ）诱导的糖尿病大鼠口服[2-¹⁴C]地西泮后，粪便和胆汁中的代谢物水平降低，同时尿中放射性升高。胰岛素治疗后这种情况可逆转。尿中代谢物排泄增加不能归因于STZ糖尿病大鼠中观察到的利尿作用。无论是在体内还是体外，均未观察到糖尿病动物中[¹⁴C]地西泮代谢的I相或II相途径有改变。静脉注射[2-¹⁴C]地西泮后，糖尿病大鼠血液中的¹⁴C水平高于正常动物。
