Dragasevic Sanja, Nikolic Andreja, Zgradic Sanja, Stojkovic Lalosevic Milica, Stojkovic Stefan, Matovic Zaric Vera, Lukic Snezana, Glisic Tijana, Kmezic Stefan, Saponjski Dusan, Popovic Dragan
Clinic for Gastroenterology and Hepatology, University Clinical Center of Serbia, Koste Todorovica 2, 11000 Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, Dr Subotica 8, 11000 Belgrade, Serbia.
Diagnostics (Basel). 2025 Jul 8;15(14):1733. doi: 10.3390/diagnostics15141733.
Microscopic colitis (MC) is an idiopathic inflammatory bowel disease characterized by watery, non-bloody diarrhea and histopathological changes but normal endoscopic findings. Increasing evidence now suggests that alterations in the gut microbiota contribute to the pathogenesis of MC. In this narrative review, we summarize evidence from nine case-control studies examining microbial composition using sequencing technology. The research presented here illustrates reduced alpha diversity, high dysbiosis, and pro-inflammatory oral-associated taxa enrichment, such as , and loss of protective microbes such as and . These microbial changes have the potential to be non-invasive diagnostic biomarkers that can differentiate MC from other etiologies. In addition, the characterization of gut microbiota in MC can guide personalized therapeutic strategies, such as directed probiotic therapy or fecal microbiota transplantation, to help restore microbial balance. These microbial patterns can be applied to guide the creation of diagnostic biomarkers and personalized therapy. Despite differences in sample types and sequencing methods, general microbial trends highlight the need for further longitudinal and standardized investigations.
显微镜下结肠炎（MC）是一种特发性炎症性肠病，其特征为水样、非血性腹泻及组织病理学改变，但内镜检查结果正常。现在越来越多的证据表明，肠道微生物群的改变有助于MC的发病机制。在这篇叙述性综述中，我们总结了九项使用测序技术检查微生物组成的病例对照研究的证据。此处呈现的研究表明，α多样性降低、高度失调、与口腔相关的促炎类群富集，如 ，以及保护性微生物如 和 的丧失。这些微生物变化有可能成为非侵入性诊断生物标志物，可将MC与其他病因区分开来。此外，MC中肠道微生物群的特征可指导个性化治疗策略，如定向益生菌治疗或粪便微生物群移植，以帮助恢复微生物平衡。这些微生物模式可用于指导诊断生物标志物的创建和个性化治疗。尽管样本类型和测序方法存在差异，但一般微生物趋势凸显了进一步进行纵向和标准化研究的必要性。
