Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation.

Asthma is a complex and heterogeneous disease characterized by chronic airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction. Despite extensive research, its underlying molecular mechanisms remain incompletely understood. Among the key immune cells involved, eosinophils play a central role in asthma pathophysiology through their contributions to Type 2 inflammation, tissue remodeling, and immune regulation. Recent studies have shown that non-coding RNAs (ncRNAs) play a crucial role in regulating eosinophil biology and contribute to the molecular mechanisms underlying asthma progression. This review consolidates the current understanding of ncRNAs in the development of eosinophils, their involvement in asthma pathogenesis, and the mechanisms underlying this process.