环状RNA的生物学功能与应用——基于RNA的新一代疗法 - Suppr

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超能文献

Biological functions and applications of circRNAs-next generation of RNA-based therapy.

作者信息

Sun Meiling, Yang Yun

机构信息

Research and Development Department, Shanghai CirCode Biomedicine Co. Ltd, Shanghai, China.

出版信息

J Mol Cell Biol. 2023 Nov 27;15(5). doi: 10.1093/jmcb/mjad031.

DOI:10.1093/jmcb/mjad031

PMID:37147015

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10708935/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d595/10708935/544b88eb0bea/mjad031fig1.jpg

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Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo.工程化的环状 ADAR 招募 RNA 可提高体外和体内 RNA 编辑的效率和保真度。

Nat Biotechnol. 2022 Jun;40(6):946-955. doi: 10.1038/s41587-021-01180-3. Epub 2022 Feb 10.

Efficient in vitro and in vivo RNA editing via recruitment of endogenous ADARs using circular guide RNAs.利用环形向导 RNA 招募内源性 ADAR 实现高效的体外和体内 RNA 编辑。

Nat Biotechnol. 2022 Jun;40(6):938-945. doi: 10.1038/s41587-021-01171-4. Epub 2022 Feb 10.

Inhibition of SARS-CoV-2 coronavirus proliferation by designer antisense-circRNAs.通过设计的反义环状 RNA 抑制 SARS-CoV-2 冠状病毒的增殖。

Nucleic Acids Res. 2021 Dec 2;49(21):12502-12516. doi: 10.1093/nar/gkab1096.

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