Zhou Jing, Ren Yaolin, Yu Jie, Zeng Yuan, Ren Jing, Wu Yifan, Zhang Qian, Xiao Xinhua
Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Crit Rev Food Sci Nutr. 2024 Dec 19:1-18. doi: 10.1080/10408398.2024.2442539.
The early intrauterine environment of mothers during pregnancy significantly affects the metabolic health of their offspring. Existing studies suggest that poor maternal nutrition during pregnancy increases the risk of obesity or diabetes in offspring, so it is highly important to intervene during pregnancy to prevent metabolic disorders in mothers and their offspring. Polyphenols with anti-inflammatory and antioxidant properties are found in many foods and have protective effects on obesity, diabetes, cancer, and cardiovascular disease. Furthermore, recent evidence indicates that maternal dietary polyphenols could be a potential therapy for improving pregnancy outcomes and offspring metabolism. In this review, we discuss the studies and mechanisms of different kinds of maternal dietary polyphenols during pregnancy and lactation in improving the metabolism of offspring, analyze the limitations of the current studies, and propose possible directions of further research, which provide new ideas and directions for reducing metabolic diseases in offspring.
孕期母亲的早期子宫内环境会显著影响其后代的代谢健康。现有研究表明，孕期母亲营养状况不佳会增加后代肥胖或患糖尿病的风险，因此在孕期进行干预以预防母亲及其后代的代谢紊乱非常重要。许多食物中都含有具有抗炎和抗氧化特性的多酚，它们对肥胖、糖尿病、癌症和心血管疾病具有保护作用。此外，最近的证据表明，母亲饮食中的多酚可能是改善妊娠结局和后代代谢的一种潜在疗法。在这篇综述中，我们讨论了孕期和哺乳期不同种类的母亲饮食多酚在改善后代代谢方面的研究及机制，分析了当前研究的局限性，并提出了可能的进一步研究方向，为降低后代代谢疾病提供了新的思路和方向。
