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孕期补充膳食月桂酸单甘油酯可通过调节微生物群促进母猪胎儿的子宫内发育和抗氧化能力。

Dietary Glyceryl Monolaurate Supplementation During Pregnancy Enhances Fetal Intrauterine Development and Antioxidant Capacity in Sows via Microbiota Modulation.

作者信息

Fu Zhichao, Wang Jun, Zhao Yueqi, Deng Tanyi, Ma Ziwei, Guan Wutai, Zeng Xiangfang, Chen Fang

机构信息

State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

Guangdong Laboratory of Modern Agriculture in Lingnan Guangdong Province, Guangzhou 510642, China.

出版信息

Antioxidants (Basel). 2025 Jun 25;14(7):783. doi: 10.3390/antiox14070783.

DOI:10.3390/antiox14070783

PMID:40722887

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12291777/

Abstract

This study elucidates the mechanisms underlying the positive effect of glyceryl monolaurate (GML) on fetal intrauterine development via maternal gut-microbiota modulating effects using a sow model. Addition of GML (1000 mg/kg) improved neonatal intestinal conditions (jejunal villus height, VH/CD ratio and tight junctions) and dorsal longissimus muscle (, and ) development in the GML-treated group. Furthermore, GML improved maternal gut microbiota composition by enriching short-chain fatty acid (SCFA)-producing bacteria and . Meanwhile, SCFA concentrations in sow feces and newborn plasma, as well as their receptors (GPR41/43) in intestine and muscle were upregulated with GML, corresponding with enhanced antioxidative and anti-inflammatory capacity. Further correlation analysis revealed and positively correlated with SCFAs, antioxidative indicators, and anti-inflammatory capacity markers. Moreover, GML inhibited the activation of the MAPK/NF-κB inflammatory signaling pathway. In summary, GML enhanced fetal intrauterine development by modulating sow intestinal SCFA-producing bacteria.

摘要

本研究使用母猪模型，通过母体肠道微生物群调节作用，阐明了月桂酸单甘油酯（GML）对胎儿宫内发育产生积极影响的潜在机制。在GML处理组中，添加GML（1000 mg/kg）改善了新生仔猪的肠道状况（空肠绒毛高度、VH/CD比值和紧密连接）以及背最长肌（、和）的发育。此外，GML通过富集产生短链脂肪酸（SCFA）的细菌和改善了母体肠道微生物群组成。同时，GML上调了母猪粪便和新生仔猪血浆中的SCFA浓度，以及肠道和肌肉中它们的受体（GPR41/43），这与增强的抗氧化和抗炎能力相关。进一步的相关性分析表明，和与SCFAs、抗氧化指标和抗炎能力标志物呈正相关。此外，GML抑制了MAPK/NF-κB炎症信号通路的激活。总之，GML通过调节母猪肠道中产生SCFA的细菌来促进胎儿宫内发育。