Li Dan, Yang Min, Ma Zhao, Che Lianqiang, Feng Bin, Fang Zhengfeng, Xu Shengyu, Zhuo Yong, Li Jian, Wang JiHhua, Zhang Zhengfan, Wu Zehui, Lin Tao, Wu De, Lin Yan
Key Laboratory of Animal Disease-Resistance Nutrition and Feed Science, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, China.
Pet Nutrition and Health Research Center, Chengdu Agricultural College, Chengdu 611130, China.
Vet Sci. 2025 Jan 7;12(1):24. doi: 10.3390/vetsci12010024.
This study aimed to investigate the effects of maternal glycerol monolaurate complex (GML) and antibiotic (acetylisovaleryltylosin tartrate, ATLL) supplementation during late gestation and lactation on the reproductive performance of sows and the growth performance of piglets. In total, 64 pregnant sows were randomly divided into control, antibiotic, 0.1% GML, and 0.2% GML groups. The GML shortened their delivery interval and farrowing duration. The ATLL increased the level of malondialdehyde (MDA) in sows and piglets and enhanced glutathione peroxidase (GSH-Px) in piglets, while reducing the tumor necrosis factor-α (TNF-α) level in sows. The GML tended to increase milk protein in the colostrum and decreased the TNF-α of sows at lactation. Meanwhile, 0.2% GML increased the serum total superoxide dismutase (T-SOD) activity and interleukin-6 level in weaned piglets and decreased the TNF-α level in sows and weaned piglets. Furthermore, ATLL decreased the microbial diversity of sows, and GML tended to increase the microbial diversity of sows and piglets. The ATLL group had an increased relative abundance of Bacteroidota in weaned piglets. The GML decreased the relative abundance of Peptostreptococcales-Tissierellales, Proteobacteria, and the harmful bacteria in sows. Compared with the ATLL group, the 0.2% GML reduced the relative abundance of Bacteroidota in weaned piglets. Interestingly, both ATLL and GML supplementation decreased the relative abundance of harmful bacteria Peptostreptococcaceae in sows. Correlation analysis also found positive effects of ATLL and GML in anti-inflammatory and antioxidant aspects. In conclusion, GML enhanced reproductive and growth performance by improving antioxidant and anti-inflammatory status and maintaining intestinal flora balance, making it a promising alternative to ATLL in future applications.
本研究旨在探讨妊娠后期和哺乳期母猪补充甘油单月桂酸酯复合物（GML）和抗生素（酒石酸乙酰异戊酰泰乐菌素，ATLL）对母猪繁殖性能和仔猪生长性能的影响。总共64头怀孕母猪被随机分为对照组、抗生素组、0.1% GML组和0.2% GML组。GML缩短了它们的分娩间隔和产仔持续时间。ATLL提高了母猪和仔猪体内丙二醛（MDA）水平，并增强了仔猪体内谷胱甘肽过氧化物酶（GSH-Px），同时降低了母猪体内肿瘤坏死因子-α（TNF-α）水平。GML倾向于增加初乳中的乳蛋白，并降低哺乳期母猪的TNF-α水平。同时，0.2% GML提高了断奶仔猪血清总超氧化物歧化酶（T-SOD）活性和白细胞介素-6水平，并降低了母猪和断奶仔猪的TNF-α水平。此外，ATLL降低了母猪的微生物多样性，而GML倾向于增加母猪和仔猪的微生物多样性。ATLL组断奶仔猪中拟杆菌门的相对丰度增加。GML降低了母猪中消化链球菌-柔膜菌纲、变形菌门和有害细菌的相对丰度。与ATLL组相比，0.2% GML降低了断奶仔猪中拟杆菌门的相对丰度。有趣的是，补充ATLL和GML均降低了母猪中有害细菌消化链球菌科的相对丰度。相关性分析还发现ATLL和GML在抗炎和抗氧化方面具有积极作用。总之，GML通过改善抗氧化和抗炎状态以及维持肠道菌群平衡来提高繁殖和生长性能，使其在未来应用中成为ATLL有前景的替代品。
