Gülüm Levent, Güler Emrah, Aktaş Fatma Lale, Çelik Ayşe Büşranur, Yılmaz Hilal, Tutar Yusuf
Department of Plant and Animal Production, Mudurnu Süreyya Astarcı Vocational College, Bolu Abant İzzet Baysal University, Bolu 14030, Türkiye.
Innovative Food Technologies Development Application and Research Center, Bolu Abant İzzet Baysal University, Bolu 14030, Türkiye.
Antioxidants (Basel). 2025 Jul 18;14(7):879. doi: 10.3390/antiox14070879.
(RC), a plant known for its traditional medicinal uses, has shown potential anticancer properties, particularly due to its rich phenolic content. Despite its promising bioactivity, its effects on breast cancer cells remain underexplored. Here, we investigated the cytotoxic effects of RC extracts on MCF-7 breast cancer cells, employing various solvents for extraction. This study revealed that the hexane extract significantly reduced the cell viability, with an IC of 9.40 µg/mL after 96 h. The gene expression analysis indicated a substantial modulation of transcriptional networks, including the upregulation of pluripotency-related genes and the downregulation of differentiation markers. The findings suggest that the RC extract may induce a shift towards a less differentiated, stem-like state in cancer cells, potentially enhancing malignancy resistance. This study underscores the potential of RC as a candidate for breast cancer treatment, and a further investigation into its therapeutic applications is suggested.
RC是一种因其传统药用价值而闻名的植物，已显示出潜在的抗癌特性，特别是由于其富含酚类物质。尽管其具有有前景的生物活性，但其对乳腺癌细胞的影响仍未得到充分研究。在此，我们使用各种溶剂进行提取，研究了RC提取物对MCF-7乳腺癌细胞的细胞毒性作用。这项研究表明，己烷提取物显著降低了细胞活力，96小时后IC50为9.40µg/mL。基因表达分析表明转录网络有显著调节，包括多能性相关基因的上调和分化标志物的下调。研究结果表明，RC提取物可能诱导癌细胞向分化程度较低的干细胞样状态转变，可能增强恶性抗性。这项研究强调了RC作为乳腺癌治疗候选药物的潜力，并建议进一步研究其治疗应用。
