Kavgacı Akif, Örün Utku Arman, Kaya Özkan, Arı Mehmet Emre
Department of Pediatric Cardiology, Ankara Etlik City Hospital, Ankara 06170, Turkey.
Children (Basel). 2025 Jul 3;12(7):879. doi: 10.3390/children12070879.
Tricuspid regurgitation (TR) is increasingly recognized as a detectable finding during routine fetal echocardiography. Although previous studies have explored its potential role as an indirect marker for congenital heart disease (CHD) in the first trimester, the prognostic significance of isolated mild TR in chromosomally normal and low-risk fetuses during the second and third trimesters remains unclear. Clarifying the clinical relevance of this commonly encountered Doppler finding is essential to guide appropriate prenatal management and avoid unnecessary interventions in low-risk pregnancies. This retrospective study reviewed fetal echocardiography reports of 1592 pregnant women referred to a pediatric cardiology clinic after the 20th gestational week between 1 January 2024 and 1 January 2025. Following exclusion criteria, 1072 low-risk pregnancies were included. A total of 136 fetuses with TR were identified, and among them, postnatal echocardiographic outcomes of 60 neonates who underwent transthoracic echocardiography within the first 10 days after birth were analyzed. Among the 1072 low-risk pregnancies included in the study, a total of 136 fetuses were diagnosed with TR on fetal echocardiography. The majority of these cases were characterized as mild and isolated, without accompanying structural abnormalities. Postnatal echocardiographic assessments revealed no major congenital cardiac anomalies, reinforcing the interpretation that isolated mild TR in the context of low-risk pregnancies represents a benign and likely transient physiological finding. Isolated mild TR, particularly in low-risk and chromosomally normal pregnancies, appears to be a transient and clinically insignificant finding. These results support the interpretation of fetal TR in the context of overall clinical and structural evaluation, helping to avoid unnecessary interventions and reduce parental anxiety.
三尖瓣反流（TR）在常规胎儿超声心动图检查中越来越多地被视为可检测到的发现。尽管先前的研究探讨了其在孕早期作为先天性心脏病（CHD）间接标志物的潜在作用，但在孕中期和孕晚期染色体正常且低风险胎儿中孤立性轻度TR的预后意义仍不明确。阐明这一常见多普勒发现的临床相关性对于指导适当的产前管理以及避免对低风险妊娠进行不必要的干预至关重要。本回顾性研究回顾了2024年1月1日至2025年1月1日期间孕20周后转诊至儿科心脏病诊所的1592名孕妇的胎儿超声心动图报告。根据排除标准，纳入了1072例低风险妊娠。共识别出136例患有TR的胎儿，其中分析了60例出生后10天内接受经胸超声心动图检查的新生儿的产后超声心动图结果。在该研究纳入的1072例低风险妊娠中，共有136例胎儿在胎儿超声心动图检查中被诊断为TR。这些病例大多数为轻度且孤立性，无伴随结构异常。产后超声心动图评估未发现重大先天性心脏异常，这进一步证明了在低风险妊娠背景下孤立性轻度TR代表一种良性且可能短暂的生理发现的解释。孤立性轻度TR，尤其是在低风险且染色体正常的妊娠中，似乎是一种短暂且临床意义不大的发现。这些结果支持在整体临床和结构评估背景下对胎儿TR的解释，有助于避免不必要的干预并减轻父母的焦虑。
