Nomura M
Yakubutsu Seishin Kodo. 1985 Sep;5(3):243-9.
The effect of 6-(10-hydroxydecyl)-2, 3-dimethoxy-5-methyl-1, 4-benzoquinone (idebenone, CV-2619) on brightness discrimination learning of the operant type was examined in rats with central serotonergic dysfunction. The animal model was produced by feeding Wistar rats a diet deficient in tryptophan (a precursor of serotonin) as the control group. The control rats with central serotonergic dysfunction showed lower ability to learn the discrimination task (multiple VI 15 seconds extinction schedule) than normal feeding rats. Rats which were chronically administered with idebenone (60 mg/kg/day) admixed with the tryptophan deficient diet were used as an experimental group. In the control and experimental groups, total responses (R+ + R-) were significantly increased in the early stage of learning test period, compared with the normal rats. In the late stage of the learning periods, the numbers of R-decreased in idebenone-treated group but not in control group. Therefore, the correct response ratio [( R+/(R+ + R-)] X 100) was significantly higher in the treated group than in the control. The results suggest that idebenone, which has an improving action on cerebral energy metabolism and a stimulating action on central serotonergic turnover, may exert an ameliorating effect on impaired discrimination learning in rats with central serotonergic dysfunction.
研究了6-(10-羟基癸基)-2,3-二甲氧基-5-甲基-1,4-苯醌（艾地苯醌，CV-2619）对中枢5-羟色胺能功能障碍大鼠操作性亮度辨别学习的影响。动物模型通过给Wistar大鼠喂食缺乏色氨酸（5-羟色胺的前体）的饮食来建立，作为对照组。中枢5-羟色胺能功能障碍的对照大鼠在学习辨别任务（多重可变间隔15秒消退程序）时的能力低于正常喂食的大鼠。将长期给予与缺乏色氨酸饮食混合的艾地苯醌（60毫克/千克/天）的大鼠作为实验组。在对照组和实验组中，与正常大鼠相比，学习测试期早期的总反应（R+ + R-）显著增加。在学习期后期，艾地苯醌治疗组的R-数量减少，而对照组未减少。因此，治疗组的正确反应率[（R+/(R+ + R-)]×100）显著高于对照组。结果表明，对脑能量代谢有改善作用且对中枢5-羟色胺能转换有刺激作用的艾地苯醌，可能对中枢5-羟色胺能功能障碍大鼠受损的辨别学习有改善作用。
