Kiyota Y, Miyamoto M, Nagaoka A
Central Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
Nihon Yakurigaku Zasshi. 1989 Mar;93(3):197-202. doi: 10.1254/fpj.93.197.
The ameliorating effects of idebenone and indeloxazine hydrochloride on the impairment of memory and learning were studied in cerebral embolized rats. The embolized rats had impaired memory and learning ability in the radial maze task; these were demonstrated by a decrease in correct responses and an increase in total errors. In particular, the rats showed severe impairment of working memory, as shown by a marked increase in the numbers of re-entries into the arm that had been already visited. Idebenone (30 mg/kg, p.o.) exerted marked ameliorating effects on the impairment in the embolized rats: the drug significantly increased the correct responses and decreased the errors. Indeloxazine hydrochloride also improved the memory impairment in the embolized rats, as shown by a reduction of the errors. The ameliorating effects of these drugs may be due mainly to improvement of hypofunctions of the central nervous system. These results confirm that idebenone and indeloxazine hydrochloride may have ameliorating actions on impairment of memory and learning induced by brain hypofunction, and they suggest that the action of idebenone is more potent than that of indeloxazine hydrochloride.
在脑栓塞大鼠中研究了艾地苯醌和盐酸茚洛秦对记忆和学习障碍的改善作用。栓塞大鼠在放射状迷宫任务中存在记忆和学习能力受损；这通过正确反应减少和总错误增加得以证明。特别是，大鼠表现出工作记忆的严重受损，表现为再次进入已访问过的臂的次数显著增加。艾地苯醌（30mg/kg，口服）对栓塞大鼠的损伤具有显著的改善作用：该药物显著增加了正确反应并减少了错误。盐酸茚洛秦也改善了栓塞大鼠的记忆损伤，表现为错误减少。这些药物的改善作用可能主要归因于中枢神经系统功能减退的改善。这些结果证实，艾地苯醌和盐酸茚洛秦可能对脑功能减退引起的记忆和学习损伤具有改善作用，并且表明艾地苯醌的作用比盐酸茚洛秦更强。
