Wüstenberg P W, Widmeyer M, Sponholz F, Schumann L, Schröder J
Z Urol Nephrol. 1985 Oct;78(10):567-80.
An investigation method concerning the renal and nephronal functional diagnostics on the experimental animal rat without analysis of microbes, without micropuncture technique and without use of inulin or paraamino-hippuric acid-analogous radiopharmaca is demonstrated. It is based on the steady state investigation principle using inulin and paraamino-hippuric acid as test substances. The exactness of the method is established by critical considerations of the methods concerning the stabilisation of the humoral balance. by estimation of the behaviour of the functional parameters after heminephrectomy as well as by comparative valuation of the own results by findings reported in literature. The established renal and nephronal functional parameters comprise glomerulofiltrative and tubulosecretory as well as tubuloreabsorptive processes in the water, sodium and paraamino-hippuric acid treatment.
展示了一种用于实验动物大鼠肾脏和肾单位功能诊断的研究方法，该方法无需分析微生物、不使用微穿刺技术且不使用菊粉或对氨基马尿酸类似的放射性药物。它基于使用菊粉和对氨基马尿酸作为测试物质的稳态研究原理。通过对体液平衡稳定方法的批判性思考、半肾切除术后功能参数行为的评估以及将自身结果与文献报道结果进行比较评估，确定了该方法的准确性。所确定的肾脏和肾单位功能参数包括在水、钠和对氨基马尿酸处理中的肾小球滤过、肾小管分泌以及肾小管重吸收过程。
