Wüstenberg P W, Hortian B, Weirich S, Kerber A, Kühnle H F
Abteilung Pathophysiologie, Universität Rostock, BRD.
J Exp Anim Sci. 1991;34(1):13-20.
Estimation of the glomerular filtration rate (GFR) and of the effective renal plasma flow (ERPF) by means of the test substances inulin and p-aminohippuric acid according to the steady state clearance measurement during the drop of the plasma level after the initially injection of an depot of the indicators was examined methodologically. The procedure should be repeatable in the same animal under conscious conditions. The results demonstrate that the described method is adequate with regard to accuracy, reproducibility and sensitivity for the estimation of the GFR, whereas limitations apply to calculation of the ERPF.
通过在最初注射指示物储存库后血浆水平下降期间根据稳态清除率测量，使用试验物质菊粉和对氨基马尿酸来估计肾小球滤过率（GFR）和有效肾血浆流量（ERPF），进行了方法学研究。该程序应能在清醒状态下的同一只动物身上重复进行。结果表明，所描述的方法在估计GFR的准确性、可重复性和敏感性方面是足够的，而在计算ERPF方面存在局限性。
