Wongta Anurak, Kyi Nan Ei Moh Moh, Samar Muhammad, Thu Nyan Lin, Pintakham Tipsuda, Hongsibsong Surat
School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Environmental, Occupational, and NCD Center of Excellent, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Healthcare (Basel). 2025 Jul 10;13(14):1671. doi: 10.3390/healthcare13141671.
BACKGROUND/OBJECTIVES: Lung function decline is influenced by metabolic risk factors (e.g., obesity, hyperglycemia, dyslipidemia) and environmental exposures (e.g., PM2.5), which may jointly contribute to airway inflammation and lung function impairment. This study aimed to investigate these associations in northern Thai adults and identify factors linked to lung function impairment.
A cross-sectional study was conducted in San Pa Thong, Chiang Mai, Thailand, involving 137 adults. Data on metabolic indicators and spirometry were collected. Statistical analyses included Spearman's correlation, multivariable linear regression, and logistic regression.
Higher triglyceride levels and shorter 6-min walk test (6MWT) distances were associated with reduced forced expiratory volume in one second (FEV) and forced vital capacity (FVC). Only 6MWT distance remained a significant factor for lung function impairment in logistic regression (adjusted OR = 0.763, 95% CI: 0.588-0.990, = 0.042).
Combining metabolic and respiratory assessments may improve early detection of lung function impairment in high-risk populations, particularly given the dual burden of metabolic disorders and air pollution in northern Thailand. These findings support the integration of metabolic and respiratory screening in community health programs to enhance preventive strategies.
背景/目的：肺功能下降受代谢风险因素（如肥胖、高血糖、血脂异常）和环境暴露（如细颗粒物2.5）影响，这些因素可能共同导致气道炎症和肺功能损害。本研究旨在调查泰国北部成年人中的这些关联，并确定与肺功能损害相关的因素。
在泰国清迈的桑帕通进行了一项横断面研究，涉及137名成年人。收集了代谢指标和肺功能测定的数据。统计分析包括Spearman相关性分析、多变量线性回归和逻辑回归。
较高的甘油三酯水平和较短的6分钟步行试验（6MWT）距离与一秒用力呼气容积（FEV）和用力肺活量（FVC）降低相关。在逻辑回归中，只有6MWT距离仍然是肺功能损害的一个重要因素（调整后的比值比=0.763，95%置信区间：0.588-0.990，P=0.042）。
结合代谢和呼吸评估可能有助于高危人群早期发现肺功能损害，特别是考虑到泰国北部代谢紊乱和空气污染的双重负担。这些发现支持在社区健康项目中整合代谢和呼吸筛查，以加强预防策略。
