[使用神经氨酸酶改善红细胞神经节苷脂诊断剂的性能]

[Use of neuraminidase for improving the properties of the erythrocytic ganglioside diagnosticum].

作者信息

Dolmatova L A, Goloseev Iu A, Narbugovich N I, Efremenko V I, Vladimtseva I V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1985 Sep(9):35-7.

Abstract

In this work the possibility of using neuraminidase for increasing the content of ganglioside GM1 in the mixture of gangliosides used for the sensitization of erythrocytes has been studied. The study has revealed that the treatment of gangliosides with neuraminidase is sufficient for obtaining active hemosensitin; there is no need for the purification of the preparation by gel filtration.

摘要

在这项工作中，研究了使用神经氨酸酶来提高用于红细胞致敏的神经节苷脂混合物中神经节苷脂GM1含量的可能性。研究表明，用神经氨酸酶处理神经节苷脂足以获得活性血致敏素；无需通过凝胶过滤对制剂进行纯化。