Takeda Y, Takeda T, Honda T, Miwatani T
Infect Immun. 1976 Jul;14(1):1-5. doi: 10.1128/iai.14.1.1-5.1976.
Biological activities of the thermostable direct hemolysin produced by Vibrio parahaemolyticus, such as its hemolytic activity and lethal activity, were inhibited by neuraminidase-sensitive gangliosides, of which GT1 ganglioside was the most inhibitory. Neuraminidase-resistant gangliosides did not affect the activities of the hemolysin. Results showed that horse erythrocytes, which are resistant to the hemolysin, do not contain the neuraminidase-sensitive gangliosides GT1 and GD1a. Therefore, we propose that neuraminidase-sensitive gangliosides, and especially GT1 ganglioside, may be the receptor sites on the membranes for the thermostable direct hemolysin of V. parahaemolyticus.
副溶血性弧菌产生的耐热直接溶血素的生物活性，如溶血活性和致死活性，受到神经氨酸酶敏感的神经节苷脂的抑制，其中GT1神经节苷脂的抑制作用最强。对神经氨酸酶有抗性的神经节苷脂不影响溶血素的活性。结果表明，对溶血素具有抗性的马红细胞不含有神经氨酸酶敏感的神经节苷脂GT1和GD1a。因此，我们提出神经氨酸酶敏感的神经节苷脂，尤其是GT1神经节苷脂，可能是副溶血性弧菌耐热直接溶血素在细胞膜上的受体位点。
