Li Man, Yu Xiaoxiao, Liu Qiang, Fang Zhi, Wang Haijun
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Int J Mol Sci. 2025 Jul 13;26(14):6723. doi: 10.3390/ijms26146723.
The temporary or permanent occlusion of cerebral blood vessels results in ischemic stroke (IS). Ischemia per se causes focal neuronal damage, and the subsequent ischemia-reperfusion injury that occurs after blood flow restoration further compromises brain tissue and cells in the neurovascular unit, significantly contributing to poor patient outcomes and functional impairments. Current research indicates that the ubiquitin-proteasome system (UPS) plays a crucial role in the pathological processes associated with cerebral ischemia-reperfusion injury (CIRI). Notably, E3 ubiquitin (Ub) ligases, which are essential in the UPS, have garnered increasing attention as potential novel therapeutic targets for treating ischemia-reperfusion damage in the brain. This review focuses primarily on the background of E3 Ub ligases and explores their intricate relationships with the pathological processes of CIRI.
脑血管的暂时或永久性闭塞会导致缺血性中风（IS）。缺血本身会导致局灶性神经元损伤，而血流恢复后发生的后续缺血再灌注损伤会进一步损害神经血管单元中的脑组织和细胞，这对患者预后不良和功能障碍有显著影响。目前的研究表明，泛素-蛋白酶体系统（UPS）在与脑缺血再灌注损伤（CIRI）相关的病理过程中起关键作用。值得注意的是，作为UPS重要组成部分的E3泛素（Ub）连接酶，作为治疗脑缺血再灌注损伤的潜在新型治疗靶点，已受到越来越多的关注。本综述主要聚焦于E3 Ub连接酶的背景，并探讨它们与CIRI病理过程的复杂关系。
