Schweiger Leyla, Meinitzer Andreas, Szolar Dieter, Brodmann Marianne, Dejaco Christian, Hafner Franz, Jud Philipp
Division of Angiology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria.
Int J Mol Sci. 2025 Jul 21;26(14):7016. doi: 10.3390/ijms26147016.
This study investigated associations of inflammation-based biomarkers with endothelial dysfunction and lipids and their predictive value for clinical outcome parameters in patients with giant cell arteritis (GCA). A total of 138 patients with inactive GCA were retrospectively analyzed to investigate potential differences in inflammatory biomarkers regarding clinical GCA subtypes and potential correlations between inflammatory parameters with markers of endothelial dysfunction and lipid parameters. Additionally, the predictive role of inflammatory biomarkers for clinical outcomes, including disease relapse, all-cause mortality, cardiovascular events, and glucocorticoid adverse effects, was analyzed. GCA individuals without concomitant symptoms of polymyalgia rheumatica and those who received initial glucocorticoid pulse therapy exhibited significantly higher levels of white blood cells and neutrophils (all with < 0.05). No other significant differences were observed between inflammatory biomarkers and clinical GCA subtypes. Additionally, significant correlations were identified between selected inflammation-based ratios and specific markers of endothelial dysfunction and lipid parameters (all with < 0.05). Elevated white blood cells and neutrophils were significant and independent predictors of disease relapse in GCA (all with < 0.05) in multiple logistic regression analysis. No significant associations were found between any other inflammatory biomarker and the occurrence of cardiovascular events, mortality, or glucocorticoid-related adverse effects. In patients with inactive GCA, selected inflammatory parameters correlated with endothelial dysfunction and dyslipidemia and may be predictive of disease relapse.
本研究调查了基于炎症的生物标志物与内皮功能障碍和血脂的关联，以及它们对巨细胞动脉炎（GCA）患者临床结局参数的预测价值。对138例非活动期GCA患者进行回顾性分析，以研究炎症生物标志物在临床GCA亚型方面的潜在差异，以及炎症参数与内皮功能障碍标志物和血脂参数之间的潜在相关性。此外，还分析了炎症生物标志物对包括疾病复发、全因死亡率、心血管事件和糖皮质激素不良反应在内的临床结局的预测作用。无风湿性多肌痛伴随症状的GCA患者以及接受初始糖皮质激素冲击治疗的患者白细胞和中性粒细胞水平显著更高（均P<0.05）。炎症生物标志物与临床GCA亚型之间未观察到其他显著差异。此外，还确定了选定的基于炎症的比值与内皮功能障碍和血脂参数的特定标志物之间存在显著相关性（均P<0.05）。在多因素逻辑回归分析中，白细胞和中性粒细胞升高是GCA疾病复发的显著且独立的预测因素（均P<0.05）。未发现任何其他炎症生物标志物与心血管事件、死亡率或糖皮质激素相关不良反应的发生之间存在显著关联。在非活动期GCA患者中，选定的炎症参数与内皮功能障碍和血脂异常相关，可能预测疾病复发。
